Results 91 to 100 of about 8,204 (252)

F7 Drives Gastric Cancer Metastasis Through Anoikis Resistance and Tumor Microenvironment Remodeling

Advanced Science, EarlyView.
ABSTRACT Coagulation factor VII (F7) has been implicated in tumor progression; however, its role in gastric cancer metastasis and immune evasion remains incompletely understood. In this study, we identified F7 as a clinically relevant driver of gastric cancer.
Lei Gao, Qinying Han, Yunpeng Wang, Xuemei Li, Bofang Wang, Baohong Gu, Weidong Li, Lin Xiang, Ying Zhang, Hao Chen   +9 more
wiley   +1 more source

Neuroinflammation and the cGAS-STING pathway [PDF]

Journal of Neurophysiology, 2019
The recent discovery of cyclic GMP-AMP synthase (cGAS) as the mammalian cytosolic DNA sensor has profound therapeutic implications for infection, immunology, and cancer. Because neurovirology, neuroimmunology, neuro-oncology, and neurodegeneration implicate cytosolic DNA sensing, cGAS activation and induction of the downstream signaling protein ...
openaire   +2 more sources

cGAS and STING are recruited to micronuclei.

, 2023
(A) Mouse fibroblasts were transfected with plasmids encoding mCherry or mCherry-cGAS (magenta), treated with 4-OHT (iKO), fixed at 1-2d, and stained with DAPI (DNA; blue). Arrowheads point to a cGAS-positive micronucleus. Scale bars, 20μm.
Shirley Guo (14515841), Elena L. Haarer (14515835), Corey J. Theodore (14515838), Kenneth G. Campellone (7921649), Ryan B. Frier (14515844)   +4 more
core   +1 more source

Versatile Co‐Engineering of Immunogenic Cell Death‐Primed Dead Tumor Cell Bodies With Tumor‐Activated MnO2 for cGAS‐STING‐Potentiated Personalized Immunotherapy

Advanced Science, EarlyView.
DTBEI@CS@MnO2, fabricated via modular electrostatic co‐engineering and photothermal/photodynamic immunogenic cell death, specifically responds to the acidic and GSH‐rich tumor microenvironment. This triggers the release of DTBEI that provides tumor antigens, DNA, and DAMPs, as well as the generation of Mn2+, thereby synergistically potentiating cGAS ...
Bolun Xu, Xuan Lu, Yuquan Wang, Haihua Ji, Ying Zhang, Yiqun Wan, Hao Wan   +6 more
wiley   +1 more source

HERC5-catalyzed ISGylation potentiates cGAS-mediated innate immunity

Cell Reports
Summary: The cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS) is essential to elicit type I interferon cascade response; thus, the activity of cGAS must be strictly regulated to boost the antiviral innate immunity.
Lei Chu, Li Qian, Yu Chen, Shengnan Duan, Ming Ding, Wu Sun, Wei Meng, Juanjuan Zhu, Quanyi Wang, Haiping Hao, Chen Wang, Shufang Cui   +11 more
doaj   +1 more source

Inhibition of cGAS DNA Sensing by a Herpesvirus Virion Protein [PDF]

, 2015
SummaryInvading viral DNA can be recognized by the host cytosolic DNA sensor, cyclic GMP-AMP (cGAMP) synthase (cGAS), resulting in production of the second messenger cGAMP, which directs the adaptor protein STING to stimulate production of type I ...
Stürzl, Michael, Whitby, Denise, Konrad, Andreas, Fu, Bishi, Gillen, Joseph, Avey, Denis, Hand, Travis, Ma, Siming, Liu, Xia, Zhu, Fanxiu, Shao, Yaming, Li, Hong, Wu, Jian-jun, Neipel, Frank, Miley, Wendell, Li, Wenwei   +15 more
core   +1 more source

SR‐A3 Promotes USP18‐Mediated deISGylation of STING to Protect Against Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
MI/RI is a major clinical challenge with high morbidity and mortality. This study demonstrates that SR‐A3 expression is downregulated in MI/RI, and its deletion exacerbates damage via the USP18/ISG15/STING axis, revealing SR‐A3 as a potential therapeutic target.
Yufei Han, Guolin Miao, Yinqi Zhao, Zhiyong Du, Kaikai Lu, Changqi Xiao, Aiden Xian, Jiaxin Duanmu, Zihao Zhou, Jinxuan Chen, Lianxin Zhang, Chao Zhai, Yitong Xu, Zhaoling Li, Xianqin Shen, Sijing Shi, Jingxuan Chen, Si Mei, Yuan Fang, Liwen Zheng, Ling Zhang, Yuhui Wang, Wei Huang, Erdan Dong, Xunde Xian   +24 more
wiley   +1 more source

SnapShot: CGAS-STING Signaling

Cell, 2018
CGAS responds to cytosolic DNA by initiating a STING-dependent response that ultimately engages innate immune effectors to ensure the preservation of organismal homeostasis.
Lorenzo, Galluzzi, Claire, Vanpouille-Box, Samuel F, Bakhoum, Sandra, Demaria   +3 more
openaire   +2 more sources

EBV‐Driven ODC1 Upregulation Enhances Polyamine Anabolism to Promote Viral Replication and Cisplatin Resistance in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
EBV‑BZLF1 initiates ODC1‑driven polyamine anabolism that correlates with poor clinical prognosis in nasopharyngeal carcinoma. The ODC1–spermidine axis promotes viral replication, cell proliferation and innate immune evasion. Pharmacological inhibition of ODC1 rescues cisplatin sensitivity, establishing ODC1 as a viable therapeutic target for EBV ...
Yueshuo Li, Xudong Hu, Chenxing Yang, Na Liu, Lin Wang, Xi Cai, Min Tang, Ya Cao, Li Shang, Feng Shi   +9 more
wiley   +1 more source

The CRL5-SPSB3 ubiquitin ligase targets nuclear cGAS for degradation [PDF]

Cyclic GMP-AMP synthase (cGAS) senses aberrant DNA during infection, cancer and inflammatory disease, and initiates potent innate immune responses through the synthesis of 2 ' 3 '-cyclic GMP-AMP (cGAMP)1-7. The indiscriminate activity of cGAS towards DNA
Ablasser, Andrea, Xu, Pengbiao, Liu, Chong, Liu, Ying, Melenec, Pauline, Guey, Baptiste, Li, Lingyun, Ricci, Jonathan   +7 more
core   +2 more sources