Results 111 to 120 of about 52,090 (308)

Nanoscale Metal–Organic Frameworks‐Mediated Degradation of Mutant p53 Proteins and Activation of cGAS‐STING Pathway for Enhanced Cancer Immunotherapy

Advancement of science
Activating cGAS‐STING pathway has great potential to achieve effective antitumor immunotherapy. However, mutant p53 (mutp53), a commonly observed genetic alteration in over 50% of human cancer, will impede the therapeutic performance of the cGAS‐STING ...
Li Sun, Hongbo Gao, Han Wang, Jingwei Zhou, Xiuru Ji, Y. Jiao, Xiaojian Qin, Dalong Ni, Xiangpeng Zheng   +8 more
semanticscholar   +1 more source

Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy

Advanced Science, EarlyView.
A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li, Daishi Li, Danyao Chen, Yating Dian, Lei Yao, Hui Su, Ziyu Guo, Deze Zhao, Zihua Wu, Furong Zeng, Chunfang Zhang, Guangtong Deng   +11 more
wiley   +1 more source

cGAS-STING targeting offers therapy choice in lung diseases

Biology Direct
Cyclic GMP/AMP (cGAMP) synthase (cGAS), along with the endoplasmic reticulum (ER)-associated stimulator of interferon genes (STING), are crucial elements of the type 1 interferon response.
Yu Wang, Xuan Zhang, Weixue Wang, Yi Zhang, Joshua S. Fleishman, Hongquan Wang   +5 more
doaj   +1 more source

Microenvironment‐Responsive Nanomedicine Enables Vertical Modulation of Mitochondrial Pathological Networks in Myocardial Ischemia–Reperfusion Injury

Advanced Science, EarlyView.
A mitochondria‐targeted, microenvironment‐responsive nanoplatform enables pH/ROS‐triggered co‐delivery of berberine and isoliensinine to orchestrate ROS scavenging, inflammation suppression, and apoptosis inhibition. This vertical modulation of mitochondrial pathological networks preserves mitochondrial function and effectively mitigates myocardial ...
Jue Wang, Jia Zhou, Wenqin Yuan, Tianjiao Zhao, Yunying Huang, Yingci Xia, Yuting Lin, Fei Li, Qiong Huang, Chong Liu, Kelong Ai, Qun Qin   +11 more
wiley   +1 more source

Eribulin induces micronuclei and enhances the nuclear localization of cGAS in triple-negative breast cancer cells

Scientific Reports
Eribulin (ERI), clinically utilized for locally advanced or metastatic breast tumors, has shown potential links to the immune system. Notably, the cGAS-STING pathway, a key component of innate immunity, has gained prominence. Yet, limited reports explore
Hideyuki Yamada, Mamoru Takada, Dhaval Ghone, Muhan Yu, Takeshi Nagashima, Hiroshi Fujimoto, Junta Sakakibara, Yoshie Hasegawa, Shintaro Takao, Akimitsu Yamada, Kazutaka Narui, Takashi Ishikawa, Aussie Suzuki, Masayuki Otsuka   +13 more
doaj   +1 more source

Megakaryocytes possess a STING pathway that is transferred to platelets to potentiate activation

Life Science Alliance
This work reveals that megakaryocytes transfer cGAS and STING proteins to platelets during thrombopoiesis and that cGAS stimulation results in the activation and aggregation of platelets, suggesting a new role of cGAS in thromboinflammation.
Firas El-Mortada, Karima Landelouci, Samuel Bertrand-Perron, Félix-Antoine Aubé, Amélie Poirier, Amel Bidias, Georges Jourdi, Mélanie Welman, Michael P Gantier, Justin R Hamilton, Benjamin Kile, Marie Lordkipanidzé, Geneviève Pépin   +12 more
doaj   +1 more source

Length does matter for cGAS

The EMBO Reports, 2017
Recognition of foreign nucleic acids by the immune system is essential to host protection against many viral and bacterial infections. It relies on the capacity of innate immune sensors to selectively distinguish self‐ and non‐self‐nucleic acids, on the basis of a variety of parameters including base modifications, sequence composition, length or ...
openaire   +2 more sources

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, EarlyView.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source

Inhibition of Cyclic GMP-AMP Synthase Ameliorates Cardiac Dysfunction in Rats After Cardiac Arrest

Cardiovascular Innovations and Applications
Cardiac dysfunction is a prevalent and serious complication after cardiac arrest (CA), yet limited therapeutic interventions are available. Cyclic GMP-AMP synthase (cGAS), a critical mediator of innate immune responses, has recently been identified as a ...
Ruiyu Wang, Ning Zhou, Yue Luo, Xiaohong Zhang, Chuanzhu Lv   +4 more
doaj   +1 more source

cGAS-activated endothelial cell–T cell cross-talk initiates tertiary lymphoid structure formation

Science immunology
Aberrant activation of the cyclic guanosine monophosphate–adenosine monophosphate synthase–stimulator of interferon genes (cGAS-STING) pathway causes autoimmunity in humans and mice; however, the exact mechanism by which the cGAS-STING pathway initiates ...
Ruibo Zhao, Jinghe Zhang, Jialu Ma, Yali Qu, Zhenrong Yang, Zhinan Yin, Fengyin Li, Zhongjun Dong, Qinmiao Sun, Shu Zhu, Zhijian J. Chen, Daxing Gao   +11 more
semanticscholar   +1 more source