Results 131 to 140 of about 52,090 (308)
Frontiers in OncologyPurposeNeoadjuvant chemo-immunotherapy (NACI) has demonstrated significant clinical advantages in head and neck squamous cell carcinomas (HNSCC), while clinical responses vary in different patients.
Miao Wang +8 more
doaj +1 more source
The cGAS-STING pathway in atherosclerosis
Frontiers in Cardiovascular MedicineAtherosclerosis (AS), a chronic inflammatory disease, remains a leading contributor to cardiovascular morbidity and mortality. Recent studies highlight the critical role of the cGAS-STING pathway—a key innate immune signaling cascade—in driving AS progression.
Si-yu Wang +10 more
openaire +3 more sources
Advanced Science, EarlyView.A novel neutrophil‐hitchhiking, rocket‐inspired nanoplatform is developed to cross the blood‐brain barrier for sequential, spatiotemporal drug delivery. By responsive surface transformation in the ischemic penumbra, it precisely targets mitochondria to suppress Drp1‐mediated fission.
He Bai +17 more
wiley +1 more source
Research and progress of cGAS/STING/NLRP3 signaling pathway: a mini review
Frontiers in ImmunologyOver the past decade, inflammasome and cGAS-STING have received significant attention as immune components that coordinate host immune homeostasis.
Ke-qian Chen, Wen-rui Tang, Xiang Liu
doaj +1 more source
Advanced Intelligent Discovery, EarlyView.Deep learning‐based denoising models are applied to DNA data storage systems to enhance error reduction and data fidelity. By integrating DnCNN with DNA sequence encoding methods, the study demonstrates significant improvements in image quality and correction of substitution errors, revealing a promising path toward robust and efficient DNA‐based ...
Seongjun Seo +5 more
wiley +1 more source
Majority‐Voting Overlapping Method for Error Correction in DNA Data Storage
Advanced Intelligent Discovery, EarlyView.We propose an overlapping‐based majority‐voting method for DNA data storage error correction. By aligning multiple reads and choosing the most frequent base per position, it suppresses substitution errors without prior models. Validated on synthetic and real sequencing data, it achieves high‐fidelity, scalable, and cost‐effective reconstruction ...
Thi Bich Ngoc Nguyen +5 more
wiley +1 more source
Distinct Domains Contribute to the Subcellular Localization of Human cGAS in Yeast
BiomoleculesCyclic GMP-AMP synthase (cGAS) functions as a DNA sensor in the cytoplasm, triggering immune responses, but it is also translocated to the nucleus, where it is kept catalytically inactive.
Sara López-Montesino +4 more
doaj +1 more source
Annals of Neurology, EarlyView.Objective Spinal muscular atrophy (SMA) is caused by deletions or mutations in the survival motor neuron 1 (SMN1) gene and subsequent reduction in the expression of survival motor neuron (SMN) protein. The disease is characterized by degeneration of α motor neurons and subsequent muscle atrophy.
Emma R. Sutton +4 more
wiley +1 more source
Advanced NanoBiomed Research, EarlyView.Bacterial membrane vesicles (BMVs) emerge as promising platforms for cancer immunotherapy owing to their intrinsic adjuvant properties and tunable cargo delivery capabilities. Their ability to modulate the tumor microenvironment, enhance antitumor immune responses, and support personalized therapeutic strategies highlights their growing potential as ...
Md Sifat Rahi +6 more
wiley +1 more source
FI-CGA and eFI-CGA in Frailty Care: a Scoping Review
Canadian Geriatrics JournalBackground Comprehensive geriatric assessment (CGA) is the reference standard for diagnosing and managing frailty. By evaluating a broad range of health, functional, cognitive, and social problems, the CGA enables the construction of a deficit accumulation Frailty Index (FI-CGA). Recent advances have integrated the electronic CGA (eCGA) into electronic
Xiaowei Song +3 more
openaire +1 more source