Results 131 to 140 of about 8,204 (252)

High cGAS-STING expression associates with improved efficacy of neoadjuvant chemo-immunotherapy in head and neck squamous cell carcinoma

Frontiers in Oncology
PurposeNeoadjuvant chemo-immunotherapy (NACI) has demonstrated significant clinical advantages in head and neck squamous cell carcinomas (HNSCC), while clinical responses vary in different patients.
Miao Wang, Menglin Shi, Yiming Ding, Zishanbai Zhang, Yuze Ge, Zhixin Li, Yixin Jing, Honglian Hu, Xiaohong Chen   +8 more
doaj   +1 more source

Transient Sleep Deprivation Induces Persistent Auditory Neuropathy via ROS‐Initiated Neuroinflammation and BK Channel Suppression

Advanced Science, EarlyView.
Sleep disturbance severity closely tracks hearing loss in a clinical cohort, yet the mechanistic link remains unclear. Acute sleep deprivation is shown to trigger transient cochlear oxidative stress that switches into a self‐sustaining neuroinflammatory state, suppressing BK channels and causing irreversible synaptopathy.
Dan Chen, Ying Ma, Lixuan Huang, Xin Chen, Fanliang Kong, Zhenzhou Qian, Mingyue Guan, Xinlin Wang, Yanyan Yang, Shasha Zhang, Peng Li, Renjie Chai   +11 more
wiley   +1 more source

Micronucleus is not a potent inducer of the cGAS/STING pathway

Life Science Alliance
The FuVis2 reporter system, designed to visualize cell nuclei harboring sister chromatid fusion, equipped with cGAS/STING reporters, offers critical insights that micronuclei are primarily captured by cGAS during mitosis but do not lead to STING ...
Yuki Sato, Makoto T Hayashi
doaj   +1 more source

Nuclear cGAS suppresses DNA repair and promotes tumorigenesis

, 2018
Accurate repair of DNA double-stranded breaks by homologous recombination preserves genome integrity and inhibits tumorigenesis. Cyclic GMP–AMP synthase (cGAS) is a cytosolic DNA sensor that activates innate immunity by initiating the STING–IRF3–type I ...
Siyu Liu, Yan, Q., Zhou, Yilong, Pei, G., Dapeng Yan, Liu, Z., Wang, J., Peng, W., Chang Chen, Liu, Siyu, Liu, Feng, Yiyan Fei, Zhang, H., Zhang, Haiping, Yan Jiang, Baoxue Ge, Liu, S., Fei, Yiyan, Liu, Haipeng, Haipeng Liu, Zheng, Ruijuan, Pei, Gang, Haohao Li, Zhu, Chenggang, Xiangyang Wu, Tang, T., Yang, H., Ma, D., Haiping Zhang, Tang, Tianqi, Yan, Qiaoling, Wu, Juehui, Wang, L., Chen, Jianxia, Hu, Zhangsen, Rong Tan, Wu, Xiangyang, Ge, B., Hu, Z., Peter Jungblut, Chen, C., Stefan H. E. Kaufmann, Yilong Zhou, Wu, J., Wang, Jie, Liang, Haijiao, Chen, J., Zhu Xu, Zhonghua Liu, Yan, Dapeng, Kaufmann, Stefan H. E., Xu, Z., Huang, X., Jianxia Chen, Ge, Baoxue, Liu, Zhonghua, Yan, D., Lin Wang, Anca Dorhoi, Mao, Zhiyong, Chenggang Zhu, Liu, F., Peng Wang, Jungblut, Peter, Wang, Peng, Tan, R., Ma, Dapeng, Gang Pei, Liang, H., Hua Yang, Zhang, Fan, Zhangsen Hu, Xu, Zhu, Wu, X., Zheng, R., Li, Haohao, Mao, Z., Tan, Rong, Dapeng Ma, Dorhoi, Anca, Zhou, Y., Wang, P., Zhiyong Mao, Zhu, C., Haijiao Liang, Xiaochen Huang, Jiang, Y., Zhang, F., Jie Wang, Yang, Hua, Liu, H., Wenxia Peng, Peng, Wenxia, Tianqi Tang, Jiang, Yan, Qiaoling Yan, Juehui Wu, Feng Liu, Fan Zhang, Ruijuan Zheng, Huang, Xiaochen, Chen, Chang, Jungblut, P., Kaufmann, S., Fei, Y., Wang, Lin, Li, H., Dorhoi, A.   +107 more
core   +1 more source

Mitochondria‐Targeted Multimodal Nanotherapeutics Suppress Oxidized mtDNA‐Driven Inflammation at the Source

Advanced Science, EarlyView.
Ox‐mtDNA fragments escaping from mitochondria drive robust inflammatory responses. A targeted nanoplatform simultaneously inhibits mitochondrial FEN1‐mediated mtDNA cleavage and scavenges ROS, preventing the generation of immunogenic Ox‐mtDNA fragments. The released SeNPs further promote autophagic clearance of cytosolic mtDNA. Consequently, cGAS‐STING,
Wen‐Ling Li, Juan Cao, Yu‐Lin Wang, Yu‐Han Fan, Jia‐Qi Xu, Xian Wu Cheng, Lei Xing, Hu‐Lin Jiang   +7 more
wiley   +1 more source

Research and progress of cGAS/STING/NLRP3 signaling pathway: a mini review

Frontiers in Immunology
Over the past decade, inflammasome and cGAS-STING have received significant attention as immune components that coordinate host immune homeostasis.
Ke-qian Chen, Wen-rui Tang, Xiang Liu
doaj   +1 more source

Intelligent Programmable Membrane Nanosponge for Early Virus Blocking

Advanced Science, EarlyView.
A smart programmable nanosponge (ACNPs) displays high‐density viral receptors on its membrane and encapsulates fusion inhibitors to capture virions at the infection source through competitive binding and blocks their entry through protease inhibition for ultra‐early cascade interception. This modular, mucus‐penetrating platform shifts antiviral defence
Ze Chen, Zhuojun He, Huimin Guo, Min Shi, Ruijing Liang, Lanlan Liu, Yeneng Dai, Qi Zhao, Ke Liu, Yang Zhou, Yang Zhang, Jian Ren, Bin Ju, Quan Fang, Zhaozhen Li, Pengfei Zhao, Mingbin Zheng, Lintao Cai   +17 more
wiley   +1 more source

Distinct Domains Contribute to the Subcellular Localization of Human cGAS in Yeast

Biomolecules
Cyclic GMP-AMP synthase (cGAS) functions as a DNA sensor in the cytoplasm, triggering immune responses, but it is also translocated to the nucleus, where it is kept catalytically inactive.
Sara López-Montesino, Julia María Coronas-Serna, Humberto Martín, María Molina, Víctor J. Cid   +4 more
doaj   +1 more source

Ribonucleotides Amplify Mitochondrial DNA‐Driven cGAS–STING Activation via FdUMP‐ribonucleotide Hybrid Particles to Potentiate Chemoimmunotherapy

Advanced Science, EarlyView.
This work develops a metabolic sharing strategy that employs cytidine monophosphate (CMP) to competitively reprogram floxuridine (FUDR) pyrimidine metabolism in colorectal tumor cells. Elevated intracellular FdUMP induces nucleotide imbalance, drives mitochondrial DNA release and cGAS‐STING innate immune cascade activation, and potentiates robust ...
Chao Wang, Chenxuan Zhao, Yesong Yao, Zhiwen Zou, Anxin Shi, Zhuo Feng, Mingkang Yang, Yue Yu, Yang Liu, Xuehui Rui, Jinhui Wu   +10 more
wiley   +1 more source

FI-CGA and eFI-CGA in Frailty Care: a Scoping Review

Canadian Geriatrics Journal
Background Comprehensive geriatric assessment (CGA) is the reference standard for diagnosing and managing frailty. By evaluating a broad range of health, functional, cognitive, and social problems, the CGA enables the construction of a deficit accumulation Frailty Index (FI-CGA). Recent advances have integrated the electronic CGA (eCGA) into electronic
Xiaowei Song, Barry Clarke, Grace Park, Kenneth Rockwood   +3 more
openaire   +1 more source