Results 151 to 160 of about 52,090 (308)

CGA Ad [PDF]

Computing in Science & Engineering, 2020
openaire   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

A bioinspired catalytic nanoplatform for ferroptosis‐immunotherapy synergy in metastatic cancer

BMEMat, EarlyView.
The bioinspired nanoplatform MnMSN@MnP‐PEG co‐delivers manganese peroxidase and manganese ions to synergistically induce immunogenic ferroptosis and activate the cGAS‐STING pathway, eliciting potent antitumor immunity against primary and metastatic tumors.
Panpan Xue, Hai Cai, Ying Sun, Yaxin Ma, Siyuan Liu, Jinying Zhu, Yan Chen, Xuemei Zeng, Shuangqian Yan   +8 more
wiley   +1 more source

Heat stress in spermatogenesis: a redox‐dependent decision network linking ROS, autophagy, and regulated cell death

Biological Reviews, EarlyView.
ABSTRACT Heat stress (HS) is an increasing threat to male reproductive health, disrupting spermatogenesis through complex and interdependent cellular responses within the seminiferous epithelium. Although excessive reactive oxygen species (ROS) production is a hallmark of HS, ROS also act as central regulators of cell fate decisions beyond their role ...
Ribrio Ivan Tavares Pereira Batista
wiley   +1 more source

Targeting the cGAS-STING pathway mitigates Huntington disease pathogenesis in a knock-in mouse model. [PDF]

Proc Natl Acad Sci U S A
Kesharwani A, Dagar S, Zuniga I, Monet MC, Halade G, Upadhyay G, Nimrod Ramírez-Jarquín U, Gisselle Lopez-Huerta V, Mirza E, Quan N, Subramaniam S.   +10 more
europepmc   +1 more source

Fhod3 in zebrafish supports myofibril stability during growth of embryonic skeletal muscle

Developmental Dynamics, EarlyView.
Abstract Background Actin filament organization in cardiomyocytes critically depends on the formin Fhod3, but a role for Fhod3 in skeletal muscle development has not yet been described. Results We demonstrate here that in zebrafish mutated for one of two fhod3 paralog genes, fhod3a, skeletal muscle of the trunk appears normal through 2 days post ...
Aubrie Russell, Tracy Eng, Jeffrey D. Amack, David Pruyne   +3 more
wiley   +1 more source

Methylation of DNA duplexes regulates cGAS-mediated innate immune activation <i>via</i> condensate formation. [PDF]

RSC Chem Biol
Morihiro K, Baba M, Yamada M, Okamoto A.
europepmc   +1 more source

Fluorescence Behavior of Water‐Soluble Porphyrins Immobilized on LTA Zeolite and Its Chlorogenic Acid Polyphenol Sensing in Coffee Wastewater

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
During coffee bean and cherry washing, contaminants are released into water, making this process a major source of water pollution. Chlorogenic acid can be efficiently detected using hybrid zeolite–porphyrin materials by measuring fluorescence quenching, achieving detection limits lower than current regulatory thresholds.
João Otávio Donizette Malafatti, Gabriele Magna, Francesco Pizzoli, Fabrizio Caroleo, Cadia D'Ottavi, Williane da Silva Freitas, Ailton José Moreira, Elaine Cristina Paris, Luiz Henrique Capparelli Mattoso, Corrado Di Natale, Roberto Paolesse   +10 more
wiley   +1 more source

Expanding roles of cGAS-STING signaling in neuroinflammation. [PDF]

J Clin Invest
Feng W, Aikedan A, Sinha SC, Gan L.
europepmc   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source