Results 171 to 180 of about 52,090 (308)

The cGAS-STING pathway in cancer immunotherapy: prognostic value and therapeutic potential. [PDF]

Front Immunol
Alabi F, Imodoye SO, Adedokun KA, Eltokhy MA, Curcic M, Okoyeocha E, Thapa I, Tiwari S, Ogundele AV, Ayo TE, Awe OB, Abd-Rouf MSK.   +11 more
europepmc   +1 more source

Microbiome—pancreatic cancer crosstalk: From tumor biology to therapeutic intervention

iMetaOmics, EarlyView.
The intratumoral microbiome acts as a critical regulator in pancreatic cancer progression and therapeutic resistance. This comprehensive review delineates the origins of pancreatic microbes, elucidates their multifaceted mechanisms in driving immune suppression, metabolic reprogramming, and stromal desmoplasia, and highlights the clinical potential of ...
Yuqin Xie, Jingyuan Ye, Sheng Wang, Maoyun Liu, Fengsheng Dai, Mingzhen Bai, Yi Wang, Athena Savoji, Yu Wang, Phillip B. Hylemon, Huiping Zhou, Hui Li, Dewei Li   +12 more
wiley   +1 more source

Autoinflammatory syndromes of STING and TREX1 dysfunction. [PDF]

J Clin Invest
Park DJ, Jones KM, Anderson JB, Finck AV, Miner JJ.   +4 more
europepmc   +1 more source

CGA Gene [PDF]

, 2020
openaire   +1 more source

Hyperoside alleviates endometrial stromal cell senescence in unexplained recurrent spontaneous abortion via DHX9‐mediated R‐loop resolution

iMeta, EarlyView.
This study suggests that the food‐derived flavonoid hyperoside may act as a natural DExH‐box helicase 9 (DHX9) modulator, directly targeting Thr419 of DHX9 to help resolve pathological R‐loop accumulation. Consequently, it suppresses cyclic GMP‐AMP synthase‐stimulator of interferon genes (cGAS‐STING)‐driven endometrial stromal senescence and restores ...
Yuepeng Jiang, Hongli Zhao, Xinyi Ding, Haoling Zhang, Yadong Guo, Yiming Ma, Lingyi Cai, Qingnan Fan, Ruisi Peng, Fuyuan Yang, Doblin Sandai, Xianling Cao, Jiali Yao, Wenyi Wang, Zhiheng Lin, Wangzheqi Zhang, Jialin He, Aihua Zhang, Xiaoxuan Zhao   +18 more
wiley   +1 more source

A dual role for cGAS in shaping cellular and organismal responses to genomic instability. [PDF]

Genes Dev
Bergman M, Goshtchevsky U, Atlan T, Astre G, Halabi R, El Ayoubi H, Moses E, Lemus AJJ, Benayoun BA, Tzfati Y, Ben-Ami I, Harel I.   +11 more
europepmc   +1 more source

Overcoming spectral limits of perovskite photodetectors for the infrared region

InfoScience, EarlyView.
Infrared (IR) photodetectors are vital for modern optoelectronics, but traditional inorganic semiconductors face limitations in cost, processing, and bandgap tunability. This review provides a summary of advanced strategies to extend metal halide perovskites into the IR region, categorizing approaches into intrinsic material engineering, physical ...
Jiean Li, Bobo Li, Mingxia Qiu, Wang Zhang, Xuan Fang   +4 more
wiley   +1 more source

Innate immune crosstalk in ALS/FTD pathogenesis. [PDF]

Cell Insight
Shu X, Yu X, Xu P, Wang A.
europepmc   +1 more source

CGAS Gene [PDF]

, 2020
openaire   +1 more source

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source