Results 161 to 170 of about 42,468 (308)

Novel Organelle‐Based Intracellular Immunity With Mechanistic and Therapeutic Implications

Barrier Immunity, EarlyView.
A conceptual framework illustrating how PAMPs/DAMPs initiate barrier, innate, adaptive, and intracellular immune responses, with organelle‐based intracellular immunity serving as a central integrator linking metabolism, inflammatory signaling, and therapeutic interventions to restore immune homeostasis.
Keman Xu, Shih‐Yu Hung, Fatma Saaoud, Ying Shao, Yifan Lu, Juanjuan Liu, Bo Yuan, Haiyan Xiang, Hong Wang, Xiaofeng Yang   +9 more
wiley   +1 more source

Fhod3 in zebrafish supports myofibril stability during growth of embryonic skeletal muscle

Developmental Dynamics, EarlyView.
Abstract Background Actin filament organization in cardiomyocytes critically depends on the formin Fhod3, but a role for Fhod3 in skeletal muscle development has not yet been described. Results We demonstrate here that in zebrafish mutated for one of two fhod3 paralog genes, fhod3a, skeletal muscle of the trunk appears normal through 2 days post ...
Aubrie Russell, Tracy Eng, Jeffrey D. Amack, David Pruyne   +3 more
wiley   +1 more source

18-β-glycyrrhetinic acid facilitates nuclear-mitochondrial communications to alleviate oxidative stress through HMGB1-cGAS-Mul1 axis in tendinopathy. [PDF]

J Transl Med
Gao YY, Sun WS, Sun ZY, Wang JR, Lv ZY, Li YJ, Tian HY, Bao ZY, Qiu XR, Wang Z, Zheng SZ, Shao JJ, Zhang ZL, Meng J.   +13 more
europepmc   +1 more source

CGAS Gene [PDF]

, 2020
openaire   +1 more source

Daily Body (Dis‐)Satisfaction and Dietary Restriction in Women Across the Eating Disorder Spectrum

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Body dissatisfaction is a key risk factor in eating disorder development: It is theorized to promote dietary restriction, thereby contributing to symptom onset. Evidence for this pathway primarily comes from cross‐sectional or multi‐wave questionnaire studies in bulimia nervosa (BN) and anorexia nervosa (AN).
Michaela R. Buehler, Ann‐Kathrin Arend, Julia Reichenberger, Jens Blechert   +3 more
wiley   +1 more source

Spleen Tyrosine Kinase (SYK) is Necessary for cGAS-STING Signaling in Müller Glia and Visual Function Deficits in Diabetic Mice. [PDF]

Glia
Yerlikaya EI, Sunilkumar S, Subrahmanian SM, Toro AL, Yeager CT, Shaikh KA, Harhaj EW, Barber AJ, Dennis MD.   +8 more
europepmc   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Human cGAS Drives LINE-1 Transcriptional Activation to Trigger MAVS-Dependent Cellular Senescence. [PDF]

Aging Cell
Chen Z, Chen L, Chen X, Wang H, Tang H, Zhen Z, Jiang Y, Mao Z, Chen Y.   +8 more
europepmc   +1 more source

Transcriptomic signatures reveal systemic adaptations and immune modulation in response to training and competitive racing in horses

Equine Veterinary Journal, EarlyView.
Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska, Jowita Grzędzicka‐Agko, Paula Kiełbik, Michał Trela, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

Roles of the cGAS-STING signaling pathway in viral latency. [PDF]

J Virol
Wu Q, Xu Q, Liu J, Zhao T.
europepmc   +1 more source