Results 81 to 90 of about 42,468 (308)

Dephosphorylation of cGAS by PPP6C impairs its substrate binding activity and innate antiviral response

Protein & Cell, 2020
The cyclic GMP-AMP (cGAMP) synthase (cGAS) plays a critical role in host defense by sensing cytosolic DNA derived from microbial pathogens or mis-located cellular DNA. Upon DNA binding, cGAS utilizes GTP and ATP as substrates to synthesize cGAMP, leading
Mi Li, Hong-Bing Shu
doaj   +1 more source

IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes [PDF]

, 2017
Many human cells can sense the presence of exogenous DNA during infection though the cytosolic DNA receptor cyclic GMP-AMP synthase (cGAS), which produces the second messenger cyclic GMP-AMP (cGAMP).
A Ablasser, A Dempsey, AM Herzner, B Zhong, CD Conrady, CK Holm, D Cuchet-Lourenço, D Gao, DL Burdette, EE Gray, FO Nestle, G Yi, GC Carter, GL Smith, H Ishikawa, H Ishikawa, H Konno, J Rehwinkel, J Zhang, K Hansen, K Mukai, KA Horan, KL Jønsson, KM Storek, KMJ Sparrer, L Li, L Strähle, L Sun, L Unterholzner, L Unterholzner, L Zhang, M Kalamvoki, MH Orzalli, MH Orzalli, MR Jakobsen, MR Thompson, N Dobbs, Q Wang, RD Everett, S Chiliveru, S Liu, T Jin, T Li, T Saitoh, T Tsuchida, V Hornung, X Cai, X Zhang, X-D Li, Y Okabe, Y Wang, Z Li, Z Zhang   +52 more
core   +5 more sources

Localized NF‐κB Inhibition Reduces Lipid Nanoparticle‐Associated Inflammation

Advanced Science, EarlyView.
Lipid nanoparticles (LNPs) activate NF‐κB and provoke inflammation that limits therapeutic delivery. By encapsulating selective NF‐κB inhibitors within LNPs, localized suppression of inflammatory signaling is achieved without compromising mRNA expression.
Carolann L. Espy, Jichuan Wu, Serena Omo‐Lamai, Liuqian Wang, Fengyi Dong, Aleksa Milosavljevic, Sarah O'Neill, Taylor Brysgel, Yufei Wang, Michael Zaleski, Emily Wolfe, Rhea Maheshwari, Manthan Patel, Dirk Trauner, Jia Nong, Zhicheng Wang, Jacob S. Brenner   +16 more
wiley   +1 more source

T cell-intrinsic cGAS-CTCF regulation maintains regulatory T cell development and function

Cell Reports
Summary: While cGAS is known as a cytosolic DNA sensor in innate immunity, its function in T cells and adaptive immunity remains uncharacterized. This study investigates the role of cGAS in regulatory T (Treg) cells.
Hongpeng Li, Yuchen Zhang, Shangze Gao, Hang Yin   +3 more
doaj   +1 more source

Topoisomerase II inhibitors induce DNA damage-dependent interferon responses circumventing Ebola virus immune evasion [PDF]

, 2017
Ebola virus (EBOV) protein VP35 inhibits production of interferon alpha/beta (IFN) by blocking RIG-I-like receptor signaling pathways, thereby promoting virus replication and pathogenesis.
Adolfo García-Sastre, Alexander Bukreyev, Ana Fernandez-Sesma, Benjamin C. Yen, Bersabeh Tigabu, Christopher F. Basler, Colette A. Pietzsch, Daisy W. Leung, Lorraine K. Morlock, Maria T. Sanchez-Aparicio, Noelle S. Williams, Priya Luthra, Sebastian Aguirre, Terence S. Dermody   +13 more
core   +3 more sources

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

A NeuroD1 AAV‐Based Gene Therapy for Functional Brain Repair in Alzheimer's Disease‐Like Non‐Human Primate Model

Advanced Science, EarlyView.
This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang, Yongpeng Qin, Bin Luo, Fan Bai, Jiangyue Liu, Long Ma, Shu He, Rongjie Chen, Yuchen Wang, Shanggong Liu, Ying Sun, Yi Chen, Shuo Zhang, Jiaqi Liang, Feng Liao, Huiyi Wei, Junjie Wei, Lu Wang, Hao Xu, Zheng Wu, Gong Chen, Wenliang Lei   +21 more
wiley   +1 more source

Streptavidin Promotes DNA Binding and Activation of cGAS to Enhance Innate Immunity

iScience, 2020
Summary: cGAS/STING signaling plays an essential role in sensing cytosolic DNA. cGAS activity is regulated by posttranslational modifications and binding partners. cGAS interactome largely includes mammalian or viral proteins.
Yanqiong Zhang, Zhe Ma, Ying Wang, Joshua Boyer, Guoxin Ni, Liang Cheng, Siyuan Su, Zhigang Zhang, Zhichuan Zhu, Jiayi Qian, Lishan Su, Qi Zhang, Blossom Damania, Pengda Liu   +13 more
doaj   +1 more source

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

RSK2-mediated cGAS phosphorylation induces cGAS chromatin-incorporation-mediated cell transformation and cancer cell colony growth

Cell Death Discovery
Cyclic guanosine-adenosine monophosphate synthase (cGAS) is a key cytosolic DNA sensor that plays a pivotal role in the innate immune response. Although a decade of research on the cGAS has advanced our understanding of inflammasome formation, cytokine ...
Weidong Chen, Ga-Eun Lee, Dohyun Jeung, Jiin Byun, Juan Wu, Xianzhe Li, Joo Young Lee, Han Chang Kang, Hye Suk Lee, Kwang Dong Kim, Soo-Bin Nam, Cheol-Jung Lee, Young Jik Kwon, Yong-Yeon Cho   +13 more
doaj   +1 more source