Results 51 to 60 of about 8,204 (252)

Nuclear cGAS restricts L1 retrotransposition by promoting TRIM41-mediated ORF2p ubiquitination and degradation

Nature Communications, 2023
Cyclic GMP–AMP synthase (cGAS), initially identified as a cytosolic DNA sensor, detects DNA fragments to trigger an innate immune response. Recently, accumulating evidence reveals the presence of cGAS within the nucleus. However, the biological functions
Zhengyi Zhen, Yu Chen, Haiyan Wang, Huanyin Tang, Haiping Zhang, Haipeng Liu, Ying Jiang, Zhiyong Mao   +7 more
doaj   +1 more source

PARP1-cGAS-NF-κB pathway of proinflammatory macrophage activation by extracellular vesicles released during Trypanosoma cruzi infection and Chagas disease

, 2020
Trypanosoma cruzi (T. cruzi) is the etiological agent of Chagas cardiomyopathy. In the present study, we investigated the role of extracellular vesicles (Ev) in shaping the macrophage (Mφ) response in progressive Chagas disease (CD). We purified T. cruzi
Nisha Jain Garg (6834830), Subhadip Choudhuri, Nisha Jain Garg, Subhadip Choudhuri (8741193)   +3 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Cyclic GMP-AMP Synthase Is Required for Cell Proliferation and Inflammatory Responses in Rheumatoid Arthritis Synoviocytes

Mediators of Inflammation, 2015
Rheumatoid arthritis (RA) is characterized by inflammatory cell infiltration, fibroblast-like synoviocytes (FLS) invasive proliferation, and joint destruction. Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor that induces immune activation.
Yan Wang, Guo-Hua Su, Fang Zhang, Jing-Xue Chu, Yun-Shan Wang   +4 more
doaj   +1 more source

Tight nuclear tethering of cGAS is essential for preventing autoreactivity

eLife, 2019
cGAS is an intracellular innate immune sensor that detects double-stranded DNA. The presence of billions of base pairs of genomic DNA in all nucleated cells raises the question of how cGAS is not constitutively activated.
Hannah E Volkman, Stephanie Cambier, Elizabeth E Gray, Daniel B Stetson   +3 more
doaj   +1 more source

Nuclear Pore Mechanotransduction in Oncology: A Structural Axis of Vulnerability for Targeted Intervention

Advanced Materials, EarlyView.
Cancer‐associated NPC remodeling creates a high‐flux, low‐stringency nuclear state that supports malignant adaptation but increases mechanical fragility. Targeting the FG‐barrier or NPC scaffold may drive mechanostat failure, envelope rupture, DNA damage, and loss of nuclear integrity.
Sílvio Terra Stefanello, Caren Rigon Mizdal, Aline Franzen da Silva, Yun Qian, Wei‐En Yuan, Victor Shahin   +5 more
wiley   +1 more source

Inhibition of cGAS Reduces Brain Injury and Facilitates Neurological Recovery via the STING-Mediated Signaling Pathway After Germinal Matrix Hemorrhage in Neonatal Mice

Journal of Integrative Neuroscience
Background: Germinal matrix hemorrhage (GMH) is a common complication of premature infants with lifelong neurological consequences. Inflammation-mediated blood-brain barrier (BBB) disruption has been implicated as a main mechanism of ...
Yiheng Wang, Xuhui Yin, Xiaoli Zhang, Xixiao Zhu, Yiting Luo, Bing-Qiao Zhao   +5 more
doaj   +1 more source

Exploring the mechanisms governing nuclear cGAS localization and activity [PDF]

, 2022
Recognition of pathogen-derived molecules through germline-encoded receptors is a fundamental principle of innate immunity. Pattern recognition receptors detect specific intracellular danger signals to trigger potent immune responses.
Wischnewski, Marilena
core   +1 more source

Melatonin alleviates neuroinflammation in ischemic stroke by regulating cyclic GMP-AMP synthase– mediated microglial pyroptosis signaling

Neural Regeneration Research
Inflammation plays a key role in driving the secondary brain injury that follows ischemic stroke. Melatonin is an endogenous neuroendocrine hormone that regulates mitochondrial homeostasis.
Qian Li, Lin Feng, Yu Tian, Erliang Guo, Yiran Li, Jingyan Niu, Haodong Pan, Chun Dang, Yaoheng Lu, Lihua Wang   +9 more
doaj   +1 more source

ZYG11B potentiates the antiviral innate immune response by enhancing cGAS-DNA binding and condensation

Cell Reports, 2023
Summary: As a key dsDNA recognition receptor, cyclic guanosine monophosphate (GMP)-AMP synthase (cGAS) plays a vital role in innate immune responses. Activated cGAS, by sensing DNA, catalyzes the synthesis of the secondary messenger cyclic GMP-AMP (cGAMP)
Jie Zhang, Er-Chi Zhou, Yan He, Ze-Lin Chai, Ben-Zhe Ji, Yi Tu, Han-Ling Wang, Wen-Qiang Wu, Yong Liu, Xing-Hua Zhang, Yu Liu   +10 more
doaj   +1 more source