Results 31 to 40 of about 8,204 (252)

PARP1-cGAS-NF-κB pathway of proinflammatory macrophage activation by extracellular vesicles released during Trypanosoma cruzi infection and Chagas disease - Fig 6

, 2020
(A) T. cruzi-induced EvDNAis oxidized. NEv and TEv were isolated from normal and T. cruzi-infected Raw Mφ (triplicate samples per group), and from normal and chronically infected WT and Parp1-/- mice (n = 10 mice per group).
Nisha Jain Garg (6834830), Subhadip Choudhuri (8741193)   +1 more
core   +1 more source

Structural basis of nucleosome-dependent cGAS inhibition [PDF]

, 2020
Cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) synthase (cGAS) recognizes cytosolic foreign or damaged DNA to activate the innate immune response to infection, inflammatory diseases, and cancer.
Boyer, J.A., Spangler, C.J., Liu, P., McGinty, R.K., Zhang, Q., Cesmat, A.P., Strauss, J.D.   +6 more
core   +1 more source

cGAS-STING signalings potentiate tumor progression via sustaining cancer stemness

Translational Oncology, 2022
The cytosolic DNA-sensing cGAS-STING pathway has been proved to be involved in tumor progression and influence the effect of cancer immunotherapy. However, little attentions have been paid to the role of cGAS-STING pathway on cancer stemness.
Fu-rao Liu, Ming-jie Jiang, Zhu Mei, Chen-jing Lin, Ling Tian   +4 more
doaj   +1 more source

Inhibition of the cGAS‐STING pathway ameliorates the premature senescence hallmarks of Ataxia‐Telangiectasia brain organoids

, 2021
Ataxia-telangiectasia (A-T) is a genetic disorder caused by the lack of functional ATM kinase. A-T is characterized by chronic inflammation, neurodegeneration and premature ageing features that are associated with increased genome instability, nuclear ...
Mackay-Sim, A, Hannah C. Leeson, Gómez-Inclán, C, Leeson, HC, Alan Mackay‐Sim, Ernst J. Wolvetang, Julio Aguado, Aguado, J, Harman K. Chaggar, Shaker, MR, Mohammed R. Shaker, Cecilia Gómez‐Inclán, Chaggar, HK, Wolvetang, EJ   +13 more
core   +1 more source

Duck cGAS inhibits DNA and RNA virus replication by activating IFNs and antiviral ISGs

Frontiers in Immunology, 2023
Cyclic GMP-AMP Synthase (cGAS) is a pivotal adaptor of the signaling pathways involving the pattern recognition receptors and plays an important role in apoptosis and immune regulation.
Chang Lin, Chang Lin, Min Zheng, Shifeng Xiao, Shao Wang, Xiaoli Zhu, Xiuqin Chen, Dandan Jiang, Xiancheng Zeng, Shaoying Chen, Shilong Chen, Shilong Chen   +11 more
doaj   +1 more source

Radiation unlocks the therapeutic potential of immune checkpoint blockers in lung cancer patients

OncoImmunology, 2019
CTLA4 blockers have limited activity in patients with chemorefractory lung cancer. Recent clinical data demonstrate that radiation therapy combined with CTLA4 blockers enables disease control in a sizeable fraction of these patients, correlating with ...
Eric C. Ko, Lorenzo Galluzzi
doaj   +1 more source

Regulation of cGAS Activity and Downstream Signaling

, 2022
Cyclic GMP-AMP synthase (cGAS) is a predominant and ubiquitously expressed cytosolic onfirmedDNA sensor that activates innate immune responses by producing a second messenger, cyclic GMP-AMP (cGAMP), and the stimulator of interferon genes (STING).
Jagdish Chandra Joshi, Dolly Mehta, Joshi, Jagdish Chandra, Joshi, Bhagwati, Bhagwati Joshi, Mehta, Dolly   +5 more
core   +1 more source

cGAS regulation and activity during genotoxic stress [PDF]

, 2020
The innate immune system has evolved to detect pathogens through germlineencoded pattern recognition receptors (PRRs). Nucleic acid sensors, a defined class of PRRs, bind to microbial and viral nucleic acids and trigger the production of type I ...
Glück, Sélène-Véronique
core   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

cGAS in human cancers

, 2021
row data of cGAS in human ...
Xue Li (11623351)
core   +1 more source