Results 31 to 40 of about 42,468 (308)
Beyond self-eating: The control of nonautophagic functions and signaling pathways by autophagy-related proteins. [PDF]
, 2017 The identification of conserved autophagy-related proteins (ATGs) that mediate bulk degradation of cytosolic material laid the foundation for breakthroughs linking autophagy to a litany of physiological processes and disease conditions.
Cadwell, Ken, Debnath, Jayanta
core +1 more source
Anisotropic selection in cellular genetic algorithms [PDF]
, 2006 In this paper we introduce a new selection scheme in cellular genetic algorithms (cGAs). Anisotropic Selection (AS) promotes diversity and allows accurate control of the selective pressure.
Clergue, Manuel +3 more
core +3 more sources
cGAS Micro-Manages Genotoxic Stress [PDF]
Immunity, 2017 Maintenance of genome integrity is essential to prevent cancer. Genotoxic stress drives damaged DNA out of the nucleus by forming micronuclei. Two studies in Nature reveal how the cytosolic DNA sensor cGAS gains access to the cargo within micronuclei to drive type I IFN responses.
Mona, Motwani, Katherine A, Fitzgerald
openaire +2 more sources
Radiation unlocks the therapeutic potential of immune checkpoint blockers in lung cancer patients
OncoImmunology, 2019 CTLA4 blockers have limited activity in patients with chemorefractory lung cancer. Recent clinical data demonstrate that radiation therapy combined with CTLA4 blockers enables disease control in a sizeable fraction of these patients, correlating with ...
Eric C. Ko, Lorenzo Galluzzi
doaj +1 more source
cGAS Dimerization Entangles DNA Recognition [PDF]
Immunity, 2013 Detection of foreign DNA in the cell cytosol triggers potent antiviral responses. In this issue of Immunity, Li et al. (2013) provide new structural and biochemical data indicating that a cytosolic DNA sensor, cyclic GMP-AMP synthase (cGAS), is activated by DNA-induced dimerization.
Kranzusch, Philip J. +1 more
openaire +2 more sources
Centrally Extended Conformal Galilei Algebras and Invariant Nonlinear PDEs
, 2015 We construct, for any given $ \ell = \frac{1}{2} + {\mathbb N}_0, $ the second-order \textit{nonlinear} partial differential equations (PDEs) which are invariant under the transformations generated by the centrally extended conformal Galilei algebras ...
Aizawa, Naruhiko, Kato, Tadanori
core +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Treatment decision-making capacity in children and adolescents hospitalized for an acute mental disorder: The role of cognitive functioning and psychiatric symptoms [PDF]
, 2017 OBJECTIVE: This study was conducted to assess treatment decision-making capacity (TDMC) in a child and adolescent psychiatric sample and to verify possible associations between TDMC, psychiatric symptom severity, and cognitive functioning.
Ferracuti, Stefano +5 more
core +1 more source
SnapShot: CGAS-STING Signaling
Cell, 2018 CGAS responds to cytosolic DNA by initiating a STING-dependent response that ultimately engages innate immune effectors to ensure the preservation of organismal homeostasis.
Lorenzo, Galluzzi +3 more
openaire +2 more sources
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source