Sea anemone model has a single Toll-like receptor that can function in pathogen detection, NF-κB signal transduction, and development [PDF]
, 2017 In organisms from insects to vertebrates, Toll-like receptors (TLRs) are primary pathogen detectors that activate downstream pathways, specifically those that direct expression of innate immune effector genes.
Brennan, Joseph J. +5 more
core +1 more source
TREX1 dictates the immune fate of irradiated cancer cells
OncoImmunology, 2017 The optimal radiation dose and fractionation to induce anti-tumor immunity remain elusive. We recently found that the exonuclease TREX1 abrogates the immunogenicity of irradiated cancer cells by degrading interferon-stimulatory cytosolic dsDNA.
Claire Vanpouille-Box +2 more
doaj +1 more source
Duck cGAS inhibits DNA and RNA virus replication by activating IFNs and antiviral ISGs
Frontiers in Immunology, 2023 Cyclic GMP-AMP Synthase (cGAS) is a pivotal adaptor of the signaling pathways involving the pattern recognition receptors and plays an important role in apoptosis and immune regulation.
Chang Lin +11 more
doaj +1 more source
Autonomous virulence adaptation improves coevolutionary optimization [PDF]
, 2011 A novel approach for the autonomous virulence adaptation (AVA) of competing populations in a coevolutionary optimization framework is presented.
Ait-Boudaoud, D, Cartlidge, J
core +2 more sources
The multifaceted functions of cGAS
Journal of Molecular Cell Biology, 2022 Abstract Pattern recognition receptors are critical for the sensing of pathogen-associated molecular patterns or danger-associated molecular patterns and subsequent mounting of innate immunity and shaping of adaptive immunity. The identification of 2′3′-cyclic guanosine monophosphate–adenosine monophosphate (cGAMP) synthase (cGAS) as a ...
Liu, Haipeng +4 more
openaire +2 more sources
An API for IPv6 Multihoming [PDF]
, 2006 IFIP International Workshop on Networked Applications, Colmenarejo, Madrid/Spain, 6?8 July, 2005This paper proposes an API for Multihoming in IPv6. This API is based on the Hash Based Addresses and Cryptographically Generated Addresses approaches, which ...
Bagnulo Braun, Marcelo Gabriel +2 more
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Roles of Emerging RNA-Binding Activity of cGAS in Innate Antiviral Response
Frontiers in Immunology, 2021 cGAS, a DNA sensor in mammalian cells, catalyzes the generation of 2’-3’-cyclic AMP-GMP (cGAMP) once activated by the binding of free DNA. cGAMP can bind to STING, activating downstream TBK1-IRF-3 signaling to initiate the expression of type I ...
Yuying Ma +25 more
doaj +1 more source
A randomized clinical trial comparing family-focused treatment and individual supportive therapy for depression in childhood and early adolescence [PDF]
, 2017 OBJECTIVE: Despite the morbidity and negative outcomes associated with early-onset depression, few studies have examined the efficacy of psychosocial treatment for depressive disorders during childhood.
Asarnow, Joan R. +3 more
core +1 more source
How to rewire the host cell: A home improvement guide for intracellular bacteria. [PDF]
, 2017 Intracellular bacterial pathogens have developed versatile strategies to generate niches inside the eukaryotic cells that allow them to survive and proliferate.
Cornejo, Elias +2 more
core +2 more sources
Clumping factors of HII, HeII and HeIII
, 2014 Estimating the intergalactic medium ionization level of a region needs proper treatment of the reionization process for a large representative volume of the universe.
Ciardi, Benedetta +2 more
core +1 more source