Results 21 to 30 of about 8,204 (252)
cGAS-STING canonical pathway is active and responsive in high risk HPV positive keratinocytes.
, 2022 (A) Western blot analysis of the canonical cGAS-STING factors upon 2’3’-cGAMP treatment. Primary keratinocytes HFKs and HFK16 cells keratinocytes were permeabilized with digitoinin and treated with 5μG/mL cGAMP for 4hrs (B) Response of downstream factors
Laimonis A. Laimins (13149963) +1 more
core +1 more source
Journal of Behçet Uz Children's Hospital, 2019 INTRODUCTION: Early-onset and very early-onset schizophrenia is a chronic disorder characterized by symptoms of thought, perception, emotion, movement, and behavior that started before the age of 18.
Burcu Serim Demirgören
doaj +1 more source
Måleegenskaper ved den norske versjonen av Children’s Global Assessment Scale (CGAS) [PDF]
, 2018 The Children’s Global Assessment Scale (CGAS), was developed by David Shaffer and colleagues at Columbia University, in 1983. The CGAS was adapted from the Global Assessment Scale for adults (GAS), and is scored by clinicians as a measure of a child’s or
Jozefiak, Thomas +2 more
core +1 more source
Cytosolic DNA sensing by cGAS: regulation, function, and human diseases
Signal Transduction and Targeted Therapy, 2021 Sensing invasive cytosolic DNA is an integral component of innate immunity. cGAS was identified in 2013 as the major cytosolic DNA sensor that binds dsDNA to catalyze the synthesis of a special asymmetric cyclic-dinucleotide, 2′3′-cGAMP, as the secondary
Le Yu, Pengda Liu
doaj +1 more source
Frontiers in Immunology, 2022 IntroductionType I interferon (IFN) plays a vital role in the pathogenesis of systemic lupus erythematosus. Cyclic GMP AMP synthase (cGAS) is a cytosolic DNA sensor that recognizes dsDNA and creates cGAMP to activate STING-mediated type I IFN production.
Sarinya Kumpunya +11 more
doaj +1 more source
TREX1 dictates the immune fate of irradiated cancer cells
OncoImmunology, 2017 The optimal radiation dose and fractionation to induce anti-tumor immunity remain elusive. We recently found that the exonuclease TREX1 abrogates the immunogenicity of irradiated cancer cells by degrading interferon-stimulatory cytosolic dsDNA.
Claire Vanpouille-Box +2 more
doaj +1 more source
Trial watch: STING agonists in cancer therapy
OncoImmunology, 2020 Stimulator of interferon response cGAMP interactor 1 (STING1, best known as STING) is an endoplasmic reticulum-sessile protein that serves as a signaling hub, receiving input from several pattern recognition receptors, most of which sense ectopic DNA ...
Julie Le Naour +4 more
doaj +1 more source
Inhibitory targeting cGAS-STING-TBK1 axis: Emerging strategies for autoimmune diseases therapy
Frontiers in Immunology, 2022 The cGAS-STING signaling plays an integral role in the host immune response, and the abnormal activation of cGAS-STING is highly related to various autoimmune diseases.
Min Zhang +7 more
doaj +1 more source
Roles of Emerging RNA-Binding Activity of cGAS in Innate Antiviral Response
Frontiers in Immunology, 2021 cGAS, a DNA sensor in mammalian cells, catalyzes the generation of 2’-3’-cyclic AMP-GMP (cGAMP) once activated by the binding of free DNA. cGAMP can bind to STING, activating downstream TBK1-IRF-3 signaling to initiate the expression of type I ...
Yuying Ma +25 more
doaj +1 more source