Results 21 to 30 of about 52,090 (308)

cGAS deficiency enhances inflammasome activation in macrophages and inflammatory pathology in pristane-induced lupus

Frontiers in Immunology, 2022
IntroductionType I interferon (IFN) plays a vital role in the pathogenesis of systemic lupus erythematosus. Cyclic GMP AMP synthase (cGAS) is a cytosolic DNA sensor that recognizes dsDNA and creates cGAMP to activate STING-mediated type I IFN production.
Sarinya Kumpunya, Arthid Thim-uam, Chisanu Thumarat, Asada Leelahavanichkul, Nuttiya Kalpongnukul, Nuttiya Kalpongnukul, Naphat Chantaravisoot, Naphat Chantaravisoot, Trairak Pisitkun, Trairak Pisitkun, Prapaporn Pisitkun, Prapaporn Pisitkun   +11 more
doaj   +1 more source

Inhibitory targeting cGAS-STING-TBK1 axis: Emerging strategies for autoimmune diseases therapy

Frontiers in Immunology, 2022
The cGAS-STING signaling plays an integral role in the host immune response, and the abnormal activation of cGAS-STING is highly related to various autoimmune diseases.
Min Zhang, Min Zhang, Yan Zou, Yan Zou, Xujun Zhou, Xujun Zhou, Jinming Zhou, Jinming Zhou   +7 more
doaj   +1 more source

TREX1 dictates the immune fate of irradiated cancer cells

OncoImmunology, 2017
The optimal radiation dose and fractionation to induce anti-tumor immunity remain elusive. We recently found that the exonuclease TREX1 abrogates the immunogenicity of irradiated cancer cells by degrading interferon-stimulatory cytosolic dsDNA.
Claire Vanpouille-Box, Silvia C. Formenti, Sandra Demaria   +2 more
doaj   +1 more source

Trial watch: STING agonists in cancer therapy

OncoImmunology, 2020
Stimulator of interferon response cGAMP interactor 1 (STING1, best known as STING) is an endoplasmic reticulum-sessile protein that serves as a signaling hub, receiving input from several pattern recognition receptors, most of which sense ectopic DNA ...
Julie Le Naour, Laurence Zitvogel, Lorenzo Galluzzi, Erika Vacchelli, Guido Kroemer   +4 more
doaj   +1 more source

Gas therapy potentiates aggregation-induced emission luminogen-based photoimmunotherapy of poorly immunogenic tumors through cGAS-STING pathway activation

Nature Communications, 2023
The immunologically “cold” microenvironment of triple negative breast cancer results in resistance to current immunotherapy. Here, we reveal the immunoadjuvant property of gas therapy with cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS ...
Kaiyuan Wang, Yang Li, Xia Wang, Zhijun Zhang, Liping Cao, Xiaoyuan Fan, Bin Wan, Fengxiang Liu, Xuanbo Zhang, Zhonggui He, Yingtang Zhou, Dong Wang, J. Sun, Xiaoyuan Chen   +13 more
semanticscholar   +1 more source

cGAS-STING signalings potentiate tumor progression via sustaining cancer stemness

Translational Oncology, 2022
The cytosolic DNA-sensing cGAS-STING pathway has been proved to be involved in tumor progression and influence the effect of cancer immunotherapy. However, little attentions have been paid to the role of cGAS-STING pathway on cancer stemness.
Fu-rao Liu, Ming-jie Jiang, Zhu Mei, Chen-jing Lin, Ling Tian   +4 more
doaj   +1 more source

Roles of Emerging RNA-Binding Activity of cGAS in Innate Antiviral Response

Frontiers in Immunology, 2021
cGAS, a DNA sensor in mammalian cells, catalyzes the generation of 2’-3’-cyclic AMP-GMP (cGAMP) once activated by the binding of free DNA. cGAMP can bind to STING, activating downstream TBK1-IRF-3 signaling to initiate the expression of type I ...
Yuying Ma, Yuying Ma, Yuying Ma, Xiaohui Wang, Xiaohui Wang, Xiaohui Wang, Weisheng Luo, Weisheng Luo, Weisheng Luo, Ji Xiao, Ji Xiao, Ji Xiao, Xiaowei Song, Xiaowei Song, Xiaowei Song, Yifei Wang, Yifei Wang, Yifei Wang, Hanlin Shuai, Zhe Ren, Zhe Ren, Zhe Ren, Yiliang Wang, Yiliang Wang, Yiliang Wang, Yiliang Wang   +25 more
doaj   +1 more source

Nonspecific DNA Binding of cGAS N Terminus Promotes cGAS Activation [PDF]

The Journal of Immunology, 2017
Abstract The cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS) mediates innate immune responses against invading pathogens, or against self-dsDNA, which causes autoimmune disorders. Upon nonspecific binding of cytosolic B–form DNA, cGAS synthesizes the second messenger 2′3′-cGAMP and triggers STING-dependent signaling to produce type I
Jianli Tao, Xiao-Wei Zhang, Jianshi Jin, Xiao-Xia Du, Tengfei Lian, Jing Yang, Xiang Zhou, Zhengfan Jiang, Xiao-Dong Su   +8 more
openaire   +2 more sources

Duck cGAS inhibits DNA and RNA virus replication by activating IFNs and antiviral ISGs

Frontiers in Immunology, 2023
Cyclic GMP-AMP Synthase (cGAS) is a pivotal adaptor of the signaling pathways involving the pattern recognition receptors and plays an important role in apoptosis and immune regulation.
Chang Lin, Chang Lin, Min Zheng, Shifeng Xiao, Shao Wang, Xiaoli Zhu, Xiuqin Chen, Dandan Jiang, Xiancheng Zeng, Shaoying Chen, Shilong Chen, Shilong Chen   +11 more
doaj   +1 more source

The cGAS–STING pathway drives type I IFN immunopathology in COVID-19

Nature, 2022
COVID-19, which is caused by infection with SARS-CoV-2, is characterized by lung pathology and extrapulmonary complications1,2. Type I interferons (IFNs) have an essential role in the pathogenesis of COVID-19 (refs 3–5).
J. D. Domizio, M. F. Gulen, F. Saidoune, Vivek V. Thacker, A. Yatim, K. Sharma, Théo Nass, E. Guenova, M. Schaller, C. Conrad, C. Goepfert, L. de Leval, C. Garnier, S. Berezowska, A. Dubois, M. Gilliet, A. Ablasser   +16 more
semanticscholar   +1 more source