Results 11 to 20 of about 52,090 (308)
The cGAS-STING pathway and cancer.
Nature Cancer, 2022 The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway has emerged as a critical innate immune pathway that, following engagement by DNA, promotes distinct immune effector responses that can impact virtually all aspects of ...
Natasha Samson, A. Ablasser
semanticscholar +3 more sources
Virologica Sinica, 2018 The cGAS-MITA pathway of cytosolic DNA sensing plays essential roles in immune response against pathogens that contain DNA or with DNA production in their life cycles. The cGAS-MITA pathway also detects leaked or aberrant accumulated self DNA in the cytoplasm under certain pathological conditions, such as virus induced cell death, DNA damage ...
Meiguang Xiong +3 more
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The multifaceted functions of cGAS
Journal of Molecular Cell Biology, 2022 Abstract Pattern recognition receptors are critical for the sensing of pathogen-associated molecular patterns or danger-associated molecular patterns and subsequent mounting of innate immunity and shaping of adaptive immunity. The identification of 2′3′-cyclic guanosine monophosphate–adenosine monophosphate (cGAMP) synthase (cGAS) as a ...
Liu, Haipeng +4 more
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Nuclear cGAS: sequestration and beyond [PDF]
Protein & Cell, 2021 AbstractThe cyclic GMP-AMP (cGAMP) synthase (cGAS) has been identified as a cytosolic double stranded DNA sensor that plays a pivotal role in the type I interferon and inflammation responses via the STING-dependent signaling pathway. In the past several years, a growing body of evidence has revealed that cGAS is also localized in the nucleus where it ...
Juli Bai, Feng Liu
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Molecular mechanisms of mitochondrial DNA release and activation of the cGAS-STING pathway
Experimental and Molecular Medicine, 2023 Cytosolic DNA activates the cGAS-STING pathway which mediates inflammation and antiviral response. One source of cytosolic DNA is ‘self ‘ DNA, such as mitochondrial DNA.
Jeongha Kim, Ho-Shik Kim, Jay H. Chung
semanticscholar +1 more source
Trial Watch: experimental TLR7/TLR8 agonists for oncological indications
OncoImmunology, 2020 Resiquimod (R848) and motolimod (VTX-2337) are second-generation experimental derivatives of imiquimod, an imidazoquinoline with immunostimulatory properties originally approved by the US Food and Drug Administration for the topical treatment of actinic ...
Giorgio Frega +6 more
doaj +1 more source
Proximity labeling reveals OTUD3 as a DNA-binding deubiquitinase of cGAS
Cell Reports, 2023 Summary: Cyclic GMP-AMP synthase (cGAS), as the major DNA sensor, initiates DNA-stimulated innate immune responses and is essential for a healthy immune system.
Heng Lyu +6 more
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Journal of Behçet Uz Children's Hospital, 2019 INTRODUCTION: Early-onset and very early-onset schizophrenia is a chronic disorder characterized by symptoms of thought, perception, emotion, movement, and behavior that started before the age of 18.
Burcu Serim Demirgören
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Tau activation of microglial cGAS–IFN reduces MEF2C-mediated cognitive resilience
Nature Neuroscience, 2023 Pathological hallmarks of Alzheimer’s disease (AD) precede clinical symptoms by years, indicating a period of cognitive resilience before the onset of dementia.
Joe C. Udeochu +28 more
semanticscholar +1 more source
Cytosolic DNA sensing by cGAS: regulation, function, and human diseases
Signal Transduction and Targeted Therapy, 2021 Sensing invasive cytosolic DNA is an integral component of innate immunity. cGAS was identified in 2013 as the major cytosolic DNA sensor that binds dsDNA to catalyze the synthesis of a special asymmetric cyclic-dinucleotide, 2′3′-cGAMP, as the secondary
Le Yu, Pengda Liu
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