Results 11 to 20 of about 42,468 (308)
Microbiology SpectrumCyclic GMP-AMP synthase (cGAS) is an important DNA pattern recognition receptor that senses double-stranded DNA derived from invading pathogens or self DNA in cytoplasm, leading to an antiviral interferon response.
Ze-zheng Jiang +9 more
doaj +3 more sources
Nuclear cGAS: sequestration and beyond [PDF]
Protein & Cell, 2021 AbstractThe cyclic GMP-AMP (cGAMP) synthase (cGAS) has been identified as a cytosolic double stranded DNA sensor that plays a pivotal role in the type I interferon and inflammation responses via the STING-dependent signaling pathway. In the past several years, a growing body of evidence has revealed that cGAS is also localized in the nucleus where it ...
Juli Bai, Feng Liu
openaire +2 more sources
Virologica Sinica, 2018 The cGAS-MITA pathway of cytosolic DNA sensing plays essential roles in immune response against pathogens that contain DNA or with DNA production in their life cycles. The cGAS-MITA pathway also detects leaked or aberrant accumulated self DNA in the cytoplasm under certain pathological conditions, such as virus induced cell death, DNA damage ...
Meiguang Xiong +3 more
openaire +2 more sources
Nonspecific DNA Binding of cGAS N Terminus Promotes cGAS Activation [PDF]
The Journal of Immunology, 2017 Abstract The cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS) mediates innate immune responses against invading pathogens, or against self-dsDNA, which causes autoimmune disorders. Upon nonspecific binding of cytosolic B–form DNA, cGAS synthesizes the second messenger 2′3′-cGAMP and triggers STING-dependent signaling to produce type I
Jianli Tao +8 more
openaire +2 more sources
Frontiers in Immunology, 2022 IntroductionType I interferon (IFN) plays a vital role in the pathogenesis of systemic lupus erythematosus. Cyclic GMP AMP synthase (cGAS) is a cytosolic DNA sensor that recognizes dsDNA and creates cGAMP to activate STING-mediated type I IFN production.
Sarinya Kumpunya +11 more
doaj +1 more source
Cytosolic DNA sensing by cGAS: regulation, function, and human diseases
Signal Transduction and Targeted Therapy, 2021 Sensing invasive cytosolic DNA is an integral component of innate immunity. cGAS was identified in 2013 as the major cytosolic DNA sensor that binds dsDNA to catalyze the synthesis of a special asymmetric cyclic-dinucleotide, 2′3′-cGAMP, as the secondary
Le Yu, Pengda Liu
doaj +1 more source
Nuclear rupture at sites of high curvature compromises retention of DNA repair factors. [PDF]
, 2018 The nucleus is physically linked to the cytoskeleton, adhesions, and extracellular matrix-all of which sustain forces, but their relationships to DNA damage are obscure. We show that nuclear rupture with cytoplasmic mislocalization of multiple DNA repair
Alshareeda +64 more
core +2 more sources
Inhibitory targeting cGAS-STING-TBK1 axis: Emerging strategies for autoimmune diseases therapy
Frontiers in Immunology, 2022 The cGAS-STING signaling plays an integral role in the host immune response, and the abnormal activation of cGAS-STING is highly related to various autoimmune diseases.
Min Zhang +7 more
doaj +1 more source
cGAS-STING signalings potentiate tumor progression via sustaining cancer stemness
Translational Oncology, 2022 The cytosolic DNA-sensing cGAS-STING pathway has been proved to be involved in tumor progression and influence the effect of cancer immunotherapy. However, little attentions have been paid to the role of cGAS-STING pathway on cancer stemness.
Fu-rao Liu +4 more
doaj +1 more source
Trial watch: STING agonists in cancer therapy
OncoImmunology, 2020 Stimulator of interferon response cGAMP interactor 1 (STING1, best known as STING) is an endoplasmic reticulum-sessile protein that serves as a signaling hub, receiving input from several pattern recognition receptors, most of which sense ectopic DNA ...
Julie Le Naour +4 more
doaj +1 more source