Nonspecific DNA Binding of cGAS N Terminus Promotes cGAS Activation [PDF]
The Journal of Immunology, 2017 Abstract The cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS) mediates innate immune responses against invading pathogens, or against self-dsDNA, which causes autoimmune disorders. Upon nonspecific binding of cytosolic B–form DNA, cGAS synthesizes the second messenger 2′3′-cGAMP and triggers STING-dependent signaling to produce type I
Jianli Tao +8 more
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Frontiers in ImmunologyAs a canonical cytoplasmic DNA sensor, cyclic GMP-AMP synthase (cGAS) plays a key role in innate immunity. In recent years, a growing number of studies have shown that cGAS can also be located in the nucleus and plays new functions such as regulating DNA damage repair, nuclear membrane repair, chromosome fusion, DNA replication, angiogenesis and other ...
Yikai Lu +5 more
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RSK2-mediated cGAS phosphorylation induces cGAS chromatin-incorporation-mediated cell transformation and cancer cell colony growth [PDF]
Cell Death DiscoveryCyclic guanosine-adenosine monophosphate synthase (cGAS) is a key cytosolic DNA sensor that plays a pivotal role in the innate immune response. Although a decade of research on the cGAS has advanced our understanding of inflammasome formation, cytokine ...
Weidong Chen +13 more
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Focus on the cGAS-STING Signaling Pathway in Sepsis and Its Inflammatory Regulatory Effects [PDF]
Journal of Inflammation ResearchYupeng Han,1,2,* Liangcheng Qiu,1,2,* Haixing Wu,1,2,* Zhiwei Song,3 Peng Ke,1,2 Xiaodan Wu1,2 1Department of Anesthesiology, Fujian Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, People’s ...
Han Y, Qiu L, Wu H, Song Z, Ke P, Wu X
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, 2021 (A) Alignment of cGAS sequences between human and pig. (B) The purification of porcine cGAS WT, cGAS S278A, and cGAS S278D protein for in vitro enzymatic assay. Visualized by Coomassie brilliant blue staining.
Ruizhen Li (1740751) +11 more
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Image_2_Type I Interferon Response Is Mediated by NLRX1-cGAS-STING Signaling in Brain Injury.PDF
, 2022 BackgroundInflammation is a significant contributor to neuronal death and dysfunction following traumatic brain injury (TBI). Recent evidence suggests that interferons may be a key regulator of this response.
Jiang Chen (583708) +13 more
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Image_4_Type I Interferon Response Is Mediated by NLRX1-cGAS-STING Signaling in Brain Injury.PDF
, 2022 BackgroundInflammation is a significant contributor to neuronal death and dysfunction following traumatic brain injury (TBI). Recent evidence suggests that interferons may be a key regulator of this response.
Jiang Chen (583708) +13 more
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Image_5_Type I Interferon Response Is Mediated by NLRX1-cGAS-STING Signaling in Brain Injury.PDF
, 2022 BackgroundInflammation is a significant contributor to neuronal death and dysfunction following traumatic brain injury (TBI). Recent evidence suggests that interferons may be a key regulator of this response.
Jiang Chen (583708) +13 more
core +1 more source
Image_1_Type I Interferon Response Is Mediated by NLRX1-cGAS-STING Signaling in Brain Injury.PDF
, 2022 BackgroundInflammation is a significant contributor to neuronal death and dysfunction following traumatic brain injury (TBI). Recent evidence suggests that interferons may be a key regulator of this response.
Jiang Chen (583708) +13 more
core +1 more source
Image_3_Type I Interferon Response Is Mediated by NLRX1-cGAS-STING Signaling in Brain Injury.PDF
, 2022 BackgroundInflammation is a significant contributor to neuronal death and dysfunction following traumatic brain injury (TBI). Recent evidence suggests that interferons may be a key regulator of this response.
Jiang Chen (583708) +13 more
core +1 more source