Results 81 to 90 of about 62,318 (309)
TREX1 dictates the immune fate of irradiated cancer cells
OncoImmunology, 2017 The optimal radiation dose and fractionation to induce anti-tumor immunity remain elusive. We recently found that the exonuclease TREX1 abrogates the immunogenicity of irradiated cancer cells by degrading interferon-stimulatory cytosolic dsDNA.
Claire Vanpouille-Box +2 more
doaj +1 more source
Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source
Effects of the STING R232/H232 Variant on the Prognosis of Inflammatory Bowel Disease
Journal of Pediatric ResearchAim: Inflammatory bowel disease (IBD) refers to a group of diseases which cause chronic and recurrent inflammation in different parts of the digestive tract, such as Crohn’s disease (CD) or ulcerative colitis (UC).
Gizem Akyol +4 more
doaj +1 more source
Influence of Honeybee Sting on Peptidome Profile in Human Serum
Toxins, 2015 The aim of this study was to explore the serum peptide profiles from honeybee stung and non-stung individuals. Two groups of serum samples obtained from 27 beekeepers were included in our study. The first group of samples was collected within 3 h after a
Jan Matysiak +4 more
doaj +1 more source
Mitochondrial control of innate immune signaling by irradiated cancer cells
OncoImmunology, 2020 Type I interferon (IFN) release by irradiated cancer cells is paramount for radiation therapy to elicit anticancer immunity. Our findings demonstrate that mitochondrial outer membrane permeabilization (MOMP) triggered by RT enables exposure of ...
Takahiro Yamazaki, Lorenzo Galluzzi
doaj +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
Acta Dermato-Venereologica, 1999 A total of 32 rosacea patients (25 with the papulopustular type of rosacea and 7 with the erythematotelangiectatic type) and 32 healthy persons were single-blind tested with a solution of 5% lactic acid and pure water applied to their cheeks.
S B, Lonne-Rahm, T, Fischer, M, Berg
openaire +2 more sources
Neural Regeneration ResearchInflammation plays a key role in driving the secondary brain injury that follows ischemic stroke. Melatonin is an endogenous neuroendocrine hormone that regulates mitochondrial homeostasis.
Qian Li +9 more
doaj +1 more source
FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source
The Lancet Regional Health. EuropeSummary: Background: Published data describing epidemiological trends of abdominal injury on a national level are scarce. This study aims to analyse trends in demographics, severity, population-adjusted incidences, and short-term outcomes of abdominal ...
Johannes Wiik Larsen +4 more
doaj +1 more source