Results 71 to 80 of about 70,402 (307)
TREX1 dictates the immune fate of irradiated cancer cells
OncoImmunology, 2017 The optimal radiation dose and fractionation to induce anti-tumor immunity remain elusive. We recently found that the exonuclease TREX1 abrogates the immunogenicity of irradiated cancer cells by degrading interferon-stimulatory cytosolic dsDNA.
Claire Vanpouille-Box +2 more
doaj +1 more source
Posterior Disconnection Syndrome in Early‐Stage Adult‐Onset Cerebral Adrenoleukodystrophy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Adult‐onset cerebral adrenoleukodystrophy is potentially treatable but often difficult to recognize before advanced cerebral involvement. Herein, we describe three men with early‐stage disease who initially presented with subtle visual complaints rather than subcortical dementia. Targeted neuropsychological testing revealed higher‐order visual
Kazuto Katsuse +13 more
wiley +1 more source
Neural Regeneration ResearchInflammation plays a key role in driving the secondary brain injury that follows ischemic stroke. Melatonin is an endogenous neuroendocrine hormone that regulates mitochondrial homeostasis.
Qian Li +9 more
doaj +1 more source
Influence of Honeybee Sting on Peptidome Profile in Human Serum
Toxins, 2015 The aim of this study was to explore the serum peptide profiles from honeybee stung and non-stung individuals. Two groups of serum samples obtained from 27 beekeepers were included in our study. The first group of samples was collected within 3 h after a
Jan Matysiak +4 more
doaj +1 more source
Mitochondrial control of innate immune signaling by irradiated cancer cells
OncoImmunology, 2020 Type I interferon (IFN) release by irradiated cancer cells is paramount for radiation therapy to elicit anticancer immunity. Our findings demonstrate that mitochondrial outer membrane permeabilization (MOMP) triggered by RT enables exposure of ...
Takahiro Yamazaki, Lorenzo Galluzzi
doaj +1 more source
Arthritis Care &Research, EarlyView.Objective The study aimed to identify symptom‐based predictors of dry eye disease (DED) signs in the Sjögren's International Collaborative Clinical Alliance (SICCA) cohort. Methods We performed a retrospective analysis examining 16 ocular symptoms (most graded 0–4) and artificial tear (AT) use (graded 0–3) as predictors of DED signs (abnormal ocular ...
Pragnya R. Donthineni +7 more
wiley +1 more source
STING-Targeted PET Imaging for Specific Detection and Therapeutic Monitoring of Myocarditis
Imaging strategies for the specific detection and therapeutic monitoring of myocarditis are still lacking. Stimulator of interferon genes (STING) is a signal transduction molecule involved in an innate immune response.
Bin Zhou (84959) +7 more
core +1 more source
Arthritis Care &Research, EarlyView.Objective The objective of this article is to identify perceptions of patients with systemic lupus erythematosus (SLE) regarding artificial intelligence (AI)–based online symptom assessment tools, and the potential of these tools to address diagnostic barriers.
Olivia A. Stein +7 more
wiley +1 more source
, 2018 Tetsuya Muto, Shigeki Machida Department of Ophthalmology, Dokkyo Medical University Saitama Medical Center, Koshigaya, Japan Purpose: Many treatments, such as conservative management or penetrating keratoplasty, exist for corneal wasp sting.
Muto T, Machida S
core
MMAE specifically enhanced the cGAMP-STING-mediated NF-kB immune response.
(A) A diagram of MMAE promoting STING-mediated NF-kB signaling. (B-E) THP1-Lucia NF-kB (WT, p50 KO and p65 KO) and THP1-Lucia ISG (WT and p65 KO) were treated with cGAMP (0.5 μM) and/or indicated doses of MMAE for 24 h.
Juanjuan Du (1729927) +5 more
core +1 more source