Results 51 to 60 of about 62,318 (309)
OncoImmunology, 2019 Caspase 3 (CASP3) has a key role in the execution of apoptosis, and many cancer cells are believed to disable CASP3 as a mechanism of resistance to cytotoxic therapeutics.
Maria Esperanza Rodriguez-Ruiz +9 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Immunity, 2014 STING (also known as MITA) is a central component in innate immunity against DNA virus. In this issue of Immunity, Wang et al. (2014) demonstrate that K27-linked polyubiquitination of STING (MITA) by the ER-associated E3 ligase AMFR is essential for STING (MITA)-mediated signaling and innate antiviral response.
Shu, Hong-Bing, Wang, Yan-Yi
openaire +2 more sources
Sting and the Sydney Symphony Australian Tour - Hunter Valley [PDF]
, 2011 Performances supporting Sting on the Sting and the Sydney Symphony Australian ...
Scholtes, Mark, Woodward, Bruce
core
Das Potenzial des Performativen in Theater, Schule und Sprach(en)bildung
TIPA. Travaux interdisciplinaires sur la parole et le langageDieser Artikel analysiert das Potenzial des Performativen für Lern- und Bildungsprozesse, insbesondere in der Theaterpädagogik und Sprachenbildung. Performatives Handeln verbindet kognitive, affektive, leiblich-körperliche und soziale Lernaspekte und ...
Wolfgang Sting
doaj +1 more source
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Wasp sting of the cornea [PDF]
, 2018 Tetsuya Muto, Shigeki Machida Department of Ophthalmology, Dokkyo Medical University Saitama Medical Center, Koshigaya, Japan Purpose: Many treatments, such as conservative management or penetrating keratoplasty, exist for corneal wasp sting.
Muto T, Machida S
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Bilateral Optic Neuritis After Bee Sting [PDF]
, 2014 Corneal edema, hyphema, lens dislocation, iris atrophy, cataract and glaucoma cases due to bee sting are frequently reported. Optic neuropathy developing after a bee sting is rarely reported. A 46-year-old man applied to our clinic with visual loss.
Haluk Esgin +3 more
core +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source