Results 41 to 50 of about 70,402 (307)

Das Potenzial des Performativen in Theater, Schule und Sprach(en)bildung

TIPA. Travaux interdisciplinaires sur la parole et le langage
Dieser Artikel analysiert das Potenzial des Performativen für Lern- und Bildungsprozesse, insbesondere in der Theaterpädagogik und Sprachenbildung. Performatives Handeln verbindet kognitive, affektive, leiblich-körperliche und soziale Lernaspekte und ...
Wolfgang Sting
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Role of STING during the development of Doxorubicin-induced cardiotoxicity in a Zebrafish model.

, 2023
reservedLa Doxorubicina è un farmaco antineoplastico frequentemente usato per il trattamento di diversi tipi di tumori. Il suo principale effetto collaterale è associato allo sviluppo di una grave forma di cardiomiopatia che può manifestarsi anche ...
PREO, GIACOMO
core  

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Novel c-di-GMP recognition modes of the mouse innate immune adaptor protein STING

, 2013
The mammalian ER protein STING (stimulator of interferon genes; also known as MITA, ERIS, MPYS or TMEM173) is an adaptor protein that links the detection of cytosolic dsDNA to the activation of TANK-binding kinase 1 (TBK1) and its downstream ...
Liang, Zhao-Xun, Chen, Hui-Chen, Yu, Yu‐Jen, Yi-Che Su, Shan-Ho Chou, Zhi-Le Tu, Lo, Yuan-Chao, Liang, Zhao‐Xun, Chou, Shan-Ho, Yu-Jen Yu, Yuan-Chao Lo, Su, Yi-Che, Barber, Glen N., Chou, Shan‐Ho, Glen N. Barber, Barber, Glen N, Chin, Ko‐Hsin, Chen, Chin-Pan, Chuah, Mary Lay‐Cheng, Tu, Zhi‐Le, Chin, Ko-Hsin, Zhao-Xun Liang, Chen, Chin‐Pan, Chen, Hui‐Chen, Tu, Zhi-Le, Lo, Yuan‐Chao, Ko-Hsin Chin, Su, Yi‐Che, Yu, Yu-Jen, Chuah, Mary Lay-Cheng, Hui-Chen Chen, Chin-Pan Chen, Mary Lay-Cheng Chuah   +32 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

STING-dependent paracriny shapes apoptotic priming of breast tumors in response to anti-mitotic treatment. Lohard et al.

, 2019
A fascinating but uncharacterized action of antimitotic chemotherapy is to collectively prime cancer cells to apoptotic mitochondrial outer membrane permeabilization (MOMP), while impacting only on cycling cell subsets.
Laurent David (157724), Steven Lohard (7881137), Fabien Gautier (4534), Sophie Barillé-Nion (3492665)   +3 more
core   +1 more source

Sting and the Sydney Symphony Australian Tour - Hunter Valley

, 2011
Performances supporting Sting on the Sting and the Sydney Symphony Australian ...
Scholtes, Mark, Woodward, Bruce
core   +1 more source