Results 21 to 30 of about 70,402 (307)

Image_1_Extracellular vesicles from A23187-treated neutrophils cause cGAS-STING-dependent IL-6 production by macrophages.tif

, 2022
In response to several types of bacteria, as well as pharmacological agents, neutrophils produce extracellular vesicles (EVs) and release DNA in the form of neutrophil extracellular traps (NETs).
Ellen M. Palmatier (13172649), Kaitlyn M. Whitefoot-Keliin (13172646), Andrew R. Mahon (337121), Mallary C. Greenlee-Wacker (13172652), Edwina R. Allen (13172643)   +4 more
core   +1 more source

Social Services, School and the Climate of Civil Society

Social Work and Society, 2007
In an international perspective cooperation between social services and school has a long tradition. In the German speaking countries we can recognize a historical distance or gap between school and “social pedagogy”, but despite this tradition new ...
Stephan Sting
doaj   +2 more sources

Adding to the STING [PDF]

Immunity, 2014
STING (also known as MITA) is a central component in innate immunity against DNA virus. In this issue of Immunity, Wang et al. (2014) demonstrate that K27-linked polyubiquitination of STING (MITA) by the ER-associated E3 ligase AMFR is essential for STING (MITA)-mediated signaling and innate antiviral response.
Shu, Hong-Bing, Wang, Yan-Yi
openaire   +2 more sources

Specific immunotherapy in Albanian patients with anaphylaxis to hymenoptera venoms [PDF]

, 2002
Background: Severe allergic reactions during rush-specific immunotherapy (Rush-SIT) may occur in the treatment of hymenoptera sting allergy. The objective of the present study was to examine the characteristics of allergic reactions during Rush-SIT in a ...
Mingomataj, Ervin, Fischer, Axel, Qirko, Etleva, Peiser, Christian, Groneberg, Jan David Alexander, Priftanji, Alfred, Dinh, Q. Thai   +6 more
core   +1 more source

Table2_Development of a risk model to predict prognosis in breast cancer based on cGAS-STING-related genes.XLSX

, 2023
Background: Breast cancer (BRCA) is regarded as a lethal and aggressive cancer with increasing morbidity and mortality worldwide. cGAS-STING signaling regulates the crosstalk between tumor cells and immune cells in the tumor microenvironment (TME ...
Zhihui Feng (748181), Junxiao Wang (6542258), David Lim (6727001), Chao Dong (291049), Chen Chen (6544)   +4 more
core   +1 more source

The STING agonist DMXAA triggers a cooperation between T lymphocytes and myeloid cells that leads to tumor regression

OncoImmunology, 2017
Regressing tumors are usually associated with a large immune infiltrate, but the molecular and cellular interactions that govern a successful anti-tumor immunity remain elusive.
Julia M. Weiss, Marion V. Guérin, Fabienne Regnier, Gilles Renault, Isabelle Galy-Fauroux, Lene Vimeux, Vincent Feuillet, Elisa Peranzoni, Maxime Thoreau, Alain Trautmann, Nadège Bercovici   +10 more
doaj   +1 more source

Manganese facilitated cGAS-STING-IFNI pathway activation induced by ionizing radiation in glioma cells

, 2023
After irradiation, double-stranded DNA leaked into the cytoplasm activates the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway, leading to the production of type I interferon (IFNI).
Ying Yang (24175), Kun Zhu (447919), Huiling Tan (500089), Yuping He (808458), Ting Sun (137181), Wei Yang (109917), Shuangyu Yang (13018273), Wenpeng Huang (12201181), Xuefei Xue (16496943)   +8 more
core   +1 more source

Negative regulator NLRC3: Its potential role and regulatory mechanism in immune response and immune-related diseases

Frontiers in Immunology, 2022
NLRC3 is a member of the pattern recognition receptors nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) family, and plays a pivotal regulatory role in modulating the activation of immune cells.
Deyi Sun, Deyi Sun, Jiqian Xu, Jiqian Xu, Wanying Zhang, Wanying Zhang, Chaoying Song, Chaoying Song, Chenggang Gao, Chenggang Gao, Yajun He, Yajun He, You Shang, You Shang   +13 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

ROLE OF THE CGAS-STING PATHWAY IN CANCER IMMUNITY AND IMMUNOTHERAPY: THE STING PATHWAY COMBINED WITH CELL THERAPY [PDF]

, 2023
openL'attivazione dell'immunità innata attraverso la stimolazione dello STING pathway si configura come una possibile via per limitare la progressione tumorale.
DELFINO, FEDERICA
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