Results 31 to 40 of about 70,402 (307)
A technique for reducing supersonic transient loads on internal wind tunnel balances [PDF]
TehnikaDesign of slender supersonic missiles requires a comprehensive experimental support in the form of wind tunnel data for a wide range of flight parameters (angle of attack and Mach number). However, in supersonic wind tunnel testing, the problem exists of
Vuković Đorđe S. +1 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Method for static divergence analysis of sting-mounted wind tunnel models [PDF]
, 2005 Occurrence of static divergence will result in a catastrophic failure of wind tunnel models supported13; on sting or other types of support . The report presents an analysis method that can be used to design and/or13; verify the design of a model-balance-
Sundaramurthy, H
core
, 2020 Left: In the mock infection, all these proteins are in the cytoplasm. NLRP3 contains an N-terminal pyrin domain (PYD), a NACHT-associated domain (NAD) and 7 C-terminal leucine rich repeats (LRR). ASC (the apoptosis-associated speck-like protein with CARD
Weijie Chen (1321836) +16 more
core +1 more source
How to Manage Lionfish Envenomation?
International Journal of Environment and Geoinformatics, 2021 Lionfish have highly toxic venom and envenomation may result in a wide spectrum of complaints in humans ranging from sharp pain to infection and necrosis of the soft tissue.
Selin Gamze SÜMEN, Bayram ÖZTÜRK
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
OncoImmunology, 2019 Caspase 3 (CASP3) has a key role in the execution of apoptosis, and many cancer cells are believed to disable CASP3 as a mechanism of resistance to cytotoxic therapeutics.
Maria Esperanza Rodriguez-Ruiz +9 more
doaj +1 more source
eHealth International, 2002 I am an optimist, but can't help noticing that disappointment follows every great invention. For a while. As athletes say, "no pain, no gain". The eHealth highway has its own detours and potholes, but we are compelled by circumstances and opportunities to travel upon it. We humans are gullible innocents.
openaire +2 more sources
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source