Results 51 to 60 of about 284,348 (246)

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Stochastic Finite-Time Stability for Stochastic Nonlinear Systems with Stochastic Impulses

Symmetry, 2022
In this paper, some novel stochastic finite-time stability criteria for stochastic nonlinear systems with stochastic impulse effects are established. The results in this paper blackgeneralized the related results in from two aspects: 1. the model in is the deterministic systems, which means that the noise effect that can be described as a symmetric ...
openaire   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Almost Periodic Solutions for Impulsive Fractional Stochastic Evolution Equations

International Journal of Analysis and Applications, 2014
In this paper, we consider the existence of square-mean piecewise almost periodic solutions for impulsive fractional stochastic evolution equations involving Caputo fractional derivative.
Toufik Guendouzi, Lamia Bousmaha
doaj   +2 more sources

Memristor-based model of neuronal excitability and synaptic potentiation

Frontiers in Neuroscience
In this manuscript, we investigate the memristor-based implementation of neuronal ion channels in a mathematical model and an experimental circuit for a neuronal oscillator. We used a FitzHugh-Nagumo equation system describing neuronal excitability.
Ivan M. Kipelkin, Ivan M. Kipelkin, Svetlana A. Gerasimova, Alexey I. Belov, Davud V. Guseinov, Alexander V. Kruglov, Dmitry A. Serov, Max O. Talanov, Max O. Talanov, Alexey N. Mikhaylov, Alexey N. Mikhaylov, Victor B. Kazantsev, Victor B. Kazantsev   +12 more
doaj   +1 more source

Bubble nucleation in a cold spin 1 gas

New Journal of Physics, 2023
Cold atomic gases offer the prospect of simulating the physics of the very early Universe in the laboratory. In the condensate phase, the gas is described by a field theory with key features of high energy particle theory.
Thomas P Billam, Kate Brown, Ian G Moss
doaj   +1 more source

Randomness, Stochasticity, and Approximations [PDF]

Theory of Computing Systems, 1997
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +3 more sources

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source