Results 61 to 70 of about 700,908 (311)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Analysis About the Effect of Dielectric Film Surface Residual Charge on Vibration of Filter Capacitor Core

Zhongguo dianli, 2022
The noise of filter power capacitor in high voltage direct current (HVDC) converters is becoming increasingly prominent. Thus, the vibration mechanism of capacitor should be further investigated to provide theoretical reference for noise reduction ...
Shuai WANG, Lin LI, Jianye CUI, Shousheng ZHAO, Pengning ZHANG, Yaqi WANG, Qiang HE   +6 more
doaj   +1 more source

Uncertainty Quantification in Computational Electromagnetics: The stochastic approach [PDF]

, 2013
Models in electromagnetism are more and more accurate. In some applications, the gap between the experience and the model comes from the deviation on input data of the model which are not perfectly known.
CLENET, Stephane
core  

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Machine Learning-Based Damage Diagnosis in Floating Wind Turbines Using Vibration Signals: A Lab-Scale Study Under Different Wind Speeds and Directions

Sensors
Floating wind turbines (FWTs) operate in offshore environments under harsh and varying operating conditions, making frequent in situ monitoring dangerous for maintenance teams and costly for operators. Remote and automated diagnosis, including the stages
John S. Korolis, Dimitrios M. Bourdalos, John S. Sakellariou   +2 more
doaj   +1 more source

Screening Routine Clinical Notes for Epilepsy Surgery Candidates Using Large Language Models

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy surgery is severely underutilized despite proven efficacy, with substantial under‐referral of eligible patients in routine clinical practice. This study evaluated the potential role of large language models (LLMs) as decision‐support tools for screening unstructured clinical notes to identify epilepsy surgery candidates and ...
Uriel Fennig, Nadav Amir, Maya Schiller, Roni Loebenstein, Johnatan Nissan, Marina Boxer, Shany Guly Gofrit, Gal Goshen, Sándor Beniczky, Nicola Maggio   +9 more
wiley   +1 more source

Bridging the Intention–Behavior Gap in Organic Food Consumption: Empirical Evidence from China

Foods
The transition to a low-carbon economy emphasizes the importance of green and low-carbon consumption; yet, there is often a discrepancy between consumers’ intentions and their actual behavior regarding organic foods.
Yaqin Liu, Peng Wang, Mengya Zhang, Xi Chen, Ke Li, Jianying Qu   +5 more
doaj   +1 more source

Characterization of Defect Distribution in an Additively Manufactured AlSi10Mg as a Function of Processing Parameters and Correlations with Extreme Value Statistics

Advanced Engineering Materials, EarlyView.
Predicting extreme defects in additive manufacturing remains a key challenge limiting its structural reliability. This study proposes a statistical framework that integrates Extreme Value Theory with advanced process indicators to explore defect–process relationships and improve the estimation of critical defect sizes. The approach provides a basis for
Muhammad Muteeb Butt, Varma Kvvssn, Hossein Laieghi, Zia Uddin, Peyman Ansari, E. Kıvanç Sadak, Can Barış Toprak, Hüseyin Kızıl, Enrico Salvati   +8 more
wiley   +1 more source

The Impact of Consumer Sentiment on Sales of New Energy Vehicles: Evidence from Textual Analysis

World Electric Vehicle Journal
The advancement of new energy vehicles (NEVs) represents a strategic initiative to combatting climate change, mitigating the energy crisis, and fostering green growth.
Yaqin Liu, Mengya Zhang, Xi Chen, Ke Li, Liwei Tang   +4 more
doaj   +1 more source