Results 161 to 170 of about 8,125 (267)

Randomised, phase 1 evaluation of the safety, tolerability, pharmacokinetics and pharmacodynamics of iptacopan in healthy volunteers

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 11, Page 2874-2889, June 2026.
Abstract Background and Purpose Overactivation of the alternative pathway (AP) underlies several diseases. Iptacopan is an oral, first‐in‐class, highly potent specific inhibitor of factor B, a key AP protease. Experimental Approach The analysis included data from two phase 1 randomised, volunteer‐blinded, placebo‐controlled studies: Study 1, a single ...
Irina Baltcheva   +5 more
wiley   +1 more source

INDIVIDUAL THYROID DOSE ESTIMATES FOR THE GENOMIC STUDY OF FOLLICULAR CARCINOMAS AND ADENOMAS IN PARTICIPANTS OF THE CHORNOBYL TISSUE BANK. [PDF]

open access: yesProbl Radiac Med Radiobiol
Masiuk SV   +16 more
europepmc   +1 more source

New Heuristics for Stable LDA Parameter Search

open access: yesComputational Intelligence, Volume 42, Issue 3, June 2026.
ABSTRACT The Latent Dirichlet Allocation (LDA) algorithm automatically extracts latent topics from a textual corpus, but configuring its parameters can be difficult and time‐consuming. Optimization algorithms can help determine the best parameters, but not necessarily the optimal ones.
Simon‐Olivier Harel   +2 more
wiley   +1 more source

Size, Returns, and Value: Do Private Equity Firms Allocate Capital According to Manager Skill?

open access: yesThe Journal of Finance, Volume 81, Issue 3, Page 1661-1700, June 2026.
ABSTRACT Using a novel data set linking private equity (PE) deals to individual managers, we document evidence of manager skill in terms of generating net present value (NPV), a performance measure that captures both scale and returns. PE firms have strong economic incentives to raise larger funds and execute larger deals.
REINER BRAUN   +3 more
wiley   +1 more source

Home - About - Disclaimer - Privacy