Results 41 to 50 of about 295,614 (312)

Stochastic gradient method with accelerated stochastic dynamics

Journal of Physics: Conference Series, 2016
12 pages, proceedings for International Meeting on High-Dimensional Data Driven Science (HD3-2015) (http://www.sparse-modeling.jp/HD3-2015/index_e.html)
openaire   +2 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Generalized Description of Intermittency in Turbulence via Stochastic Methods

Atmosphere, 2020
We present a generalized picture of intermittency in turbulence that is based on the theory of stochastic processes. To this end, we rely on the experimentally and numerically verified finding by R. Friedrich and J. Peinke [Phys. Rev. Lett. 78, 863 (1997)
Jan Friedrich, Rainer Grauer
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Recent Design Optimization Methods for Energy-Efficient Electric Motors and Derived Requirements for a New Improved Method—Part 1

Proceedings, 2018
Energy-efficient electric motors are gathering an increased attention since they are used in electric cars or to reduce operational costs, for instance.
Johannes Schmelcher, Max Kleine Büning, Kai Kreisköther, Dieter Gerling, Achim Kampker   +4 more
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Strong first order S-ROCK methods for stochastic differential equations [PDF]

, 2012
Explicit stochastic Runge–Kutta (SRK) methods are constructed for non-commutative Itô and Stratonovich stochastic differential equations. Our aim is to derive explicit SRK schemes of strong order one, which are derivative free and have large stability ...
コモリ, ヨシオ, 7101844227, Burrage, Kevin, 20285430, Burrage, K., Komori, Yoshio, 3142, 16896, 小守, 良雄, Komori, Y., 241   +10 more
core   +1 more source

Stochastic Runge–Kutta methods for multi-dimensional Itô stochastic differential algebraic equations

Results in Applied Mathematics, 2021
In this paper, we discuss the numerical solutions to index 1 stochastic differential algebraic equations. We introduce a new class of weak second-order stochastic Runge–Kutta methods for finding the numerical approximate solutions to multi-dimensional ...
Priya Nair, Anandaraman Rathinasamy
doaj   +1 more source

Stochastic average model methods

Computational Optimization and Applications
We consider the solution of finite-sum minimization problems, such as those appearing in nonlinear least-squares or general empirical risk minimization problems. We are motivated by problems in which the summand functions are computationally expensive and evaluating all summands on every iteration of an optimization method may be undesirable.
Matt Menickelly, Stefan M. Wild
openaire   +4 more sources