Results 41 to 50 of about 12,651,285 (254)

Approximating Hessian matrices using Bayesian inference: a new approach for quasi-Newton methods in stochastic optimization [PDF]

open access: yes
Using quasi-Newton methods in stochastic optimization is not a trivial task given the difficulty of extracting curvature information from the noisy gradients. Moreover, pre-conditioning noisy gradient observations tend to amplify the noise.
Espath, Luis   +2 more
core   +1 more source

A priori error indicator in the transformation method for problems with geometric uncertainties [PDF]

open access: yes, 2013
Version éditeur de cette publication à l'adresse suivante : http://ieeexplore.ieee.org/xpl/articleDetails.jsp?arnumber=6514655To solve stochastic problems with geometric uncertainties, one can transform the original problem in a domain with stochastic ...
Mac, Duc Hung   +4 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Fast and Reliable Human Exposure Assessment Around High Power Systems Using Surrogate Modeling

open access: yesIEEE Access
Due to the high level of magnetic stray field around high power electromagnetic systems, the human exposure needs to be properly assessed in order to check the compliance with international standards and guidelines.
Paul Lagouanelle   +3 more
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

open access: yesMolecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth   +17 more
wiley   +1 more source

Computational Methods for Complex Stochastic Systems: A Review of Some Alternatives to MCMC. [PDF]

open access: yes, 2008
We consider analysis of complex stochastic models based upon partial information. MCMC and reversible jump MCMC are often the methods of choice for such problems, but in some situations they can be difficult to implement; and suffer from problems such as
Fearnhead, Paul, Paul Fearnhead
core   +3 more sources

Experimental Study of Lidar System for a Static Object in Adverse Weather Conditions

open access: yesJournal of Sensor and Actuator Networks
Thanks to light detection and ranging (LiDAR), unmanned ground vehicles (UGVs) are able to detect different objects in their environment and measure the distance between them. This device gives the ability to see its surroundings in real time.
Saulius Japertas   +2 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso   +5 more
wiley   +1 more source

Continuous stage stochastic Runge–Kutta methods

open access: yesAdvances in Difference Equations, 2021
In this work, a version of continuous stage stochastic Runge–Kutta (CSSRK) methods is developed for stochastic differential equations (SDEs). First, a general order theory of these methods is established by the theory of stochastic B-series and ...
Xuan Xin, Wendi Qin, Xiaohua Ding
doaj   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

open access: yesFEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta   +7 more
wiley   +1 more source

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