Results 41 to 50 of about 1,362,476 (292)

Evaluating the impact and cost-effectiveness of chlamydia management strategies in Hong Kong: A modeling study

Frontiers in Public Health, 2022
ObjectivesTo illustrate the epidemiologic and cost-effectiveness impact of shifting the focus from population-based screening toward a targeted management approach for genital chlamydia infection.DesignModeling study, implementing an individual-based ...
Sandra Montes-Olivas, Yaz Ozten, Martin Homer, Katy Turner, Katy Turner, Christopher K. Fairley, Christopher K. Fairley, Jane S. Hocking, Desiree Tse, Nicolas Verschueren van Rees, Nicolas Verschueren van Rees, William C. W. Wong, Jason J. Ong, Jason J. Ong, Jason J. Ong   +14 more
doaj   +1 more source

Stochastic model for cell polarity

, 2012
Cell polarity refers to the spatial asymmetry of molecules on the cell membrane. Altschuler, Angenent, Wang and Wu have proposed a stochastic model for studying the emergence of polarity in the presence of feedback between molecules.
Gupta, Ankit
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

On the stochastic modeling and forecasting of the $ \mathscr{SVIR} $ epidemic dynamic model under environmental white noise

AIMS Mathematics
This study introduced a novel $ \mathscr{SVIR} $ epidemic model incorporating environmental white noise to account for stochastic fluctuations in disease transmission. The model was analyzed to determine conditions for disease persistence and extinction,
Shah Hussain, Naveed Iqbal, Elissa Nadia Madi, Mohsen Bakouri, Ilyas Khan, Wei Sin Koh   +5 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Experimental and Modeling Approaches for Understanding the Effect of Gene Expression Noise in Biological Development

Frontiers in Physics, 2018
Biological development involves numerous chemical and physical processes which must act in concert to reliably produce a cell, a tissue, or a body.
David M. Holloway, David M. Holloway
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Revisiting Online Algorithms: A Survey of Set Cover Solutions Beyond Competitive Analysis

IEEE Access
Online algorithms are crucial for real-time decision-making and adaptability across diverse fields, such as operations research, computer science, and combinatorics. These algorithms handle data incrementally and make decisions without prior knowledge of
Christine Markarian, Claude Fachkha, Noura Yassine   +2 more
doaj   +1 more source

Role of Media and Effects of Infodemics and Escapes in the Spatial Spread of Epidemics: A Stochastic Multi-Region Model with Optimal Control Approach

Mathematics, 2019
Mass vaccination campaigns play major roles in the war against epidemics. Such prevention strategies cannot always reach their goals significantly without the help of media and awareness campaigns used to prevent contacts between susceptible and infected
Fadwa El Kihal, Imane Abouelkheir, Mostafa Rachik, Ilias Elmouki   +3 more
doaj   +1 more source