Results 41 to 50 of about 193,926 (266)
On Importance of Sensitivity Analysis on an Example of a k-out-of-n System
Mathematics, 2023 Reliability and sensitivity issues are very close and important problems in any technical system. The system’s sensitivity is understood as the dependence of its behavior on changes in some internal parameters.
Nika Ivanova
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Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
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Frontiers in Applied Mathematics and StatisticsIn this study, we investigate the issue of estimating the mean vector of a multivariate normal distribution. We introduce two new families of shrinkage estimators derived from both the maximum likelihood estimator and the James-Stein estimator.
Najla M. ALoraini +2 more
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Engenharia Agrícola, 2010 Este trabalho teve como objetivo avaliar a modelagem matemática da precipitação pluviométrica horária por meio do modelo de Bartlett-Lewis modificado com seis parâmetros e sua aplicação para estimativa de eventos extremos.
Álvaro J. Back, Edison Uggioni
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Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
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Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
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Local Linear Regression for Functional Ergodic Data with Missing at Random Responses
MathematicsIn this article, we develop a novel kernel-based estimation framework for functional regression models in the presence of missing responses, with particular emphasis on the Missing At Random (MAR) mechanism.
Yassine Baghli +2 more
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Special Issue on “Terrestrial Laser Scanning”: Editors’ Notes
Sensors, 2019 In this editorial, we provide an overview of the content of the special issue on “Terrestrial Laser Scanning”. The aim of this Special Issue is to bring together innovative developments and applications of terrestrial laser scanning (TLS ...
Joan R. Rosell-Polo +2 more
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Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
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New Approaches of Stochastic Models to Examine the Vibration Features in Roller Bearings
Applied SciencesMachinery components undergo wear and tear over time due to regular usage, necessitating the establishment of a robust prognosis framework to enhance machinery health and avert catastrophic failures.
Saima Bhatti +3 more
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