Model‐Driven Optimization of Subcutaneous Polymer Prodrugs Achieves Cancer Remission in Mice
A pharmacokinetics/pharmacodynamics (PK/PD) model was developed to evaluate multiple dosing regimens for subcutaneously administered water‐soluble polymer prodrug for cancer therapy. The model enabled prediction of in vivo performance and contributed to the optimization of anticancer efficacy.
Anne Rodallec +5 more
wiley +1 more source
Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration
Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu +4 more
wiley +1 more source
Bioinspired Adaptive Sensors: A Review on Current Developments in Theory and Application
This review comprehensively summarizes the recent progress in the design and fabrication of sensory‐adaptation‐inspired devices and highlights their valuable applications in electronic skin, wearable electronics, and machine vision. The existing challenges and future directions are addressed in aspects such as device performance optimization ...
Guodong Gong +12 more
wiley +1 more source
STATIONARY STOCHASTIC INPUT FLOW MODELING OF BRANCHED CONVEYOR SYSTEMS
The object of research is stochastic stationary input material flow of a conveyor-type transport system. Subject of research is a method for generating realizations of a stationary stochastic input flow of material on the basis of experimental data. The
Oleh Pihnastyi +2 more
doaj +1 more source
Increasing Inundation Frequencies Enhance the Stochastic Process and Network Complexity of the Soil Archaeal Community in Coastal Wetlands. [PDF]
Gao GF, Peng D, Wu D, Zhang Y, Chu H.
europepmc +1 more source
Intelligent Acousto‐Electrical Metamaterials (IAM) for Sound Source Detection
Our proposed metamaterial concept enables sound source detection using a single material, in contrast to conventional arrays that require dozens or even hundreds of transducers. We show that the coupled acoustic–vibrational–electrical responses in piezoelectric metamaterials give rise to topology‐governed charge transport, producing distinct voltage ...
Victor Couëdel +7 more
wiley +1 more source
Jump Diffusion Modelling for the Brazilian Short-Term Interest Rate
In order to capture the informational effect of the Brazilian short-term interest rate (SELIC rate) by Poisson jumps, we build on the tests condu cted by Das (2002) and Johannes (2004), which show the significance of such structures for U.S ...
José Carlos Nogueira Cavalcante Filho +1 more
doaj
Homogeneous stochastic processes [PDF]
openaire +2 more sources
Ordered three‐dimensional anodic aluminum oxide (3D‐AAO) nanoarchitectures with longitudinal and transverse pores enable architecture‐driven metamaterials. The review maps fabrication advances, including hybrid pulse anodization, and shows how 3D‐AAO templates tailor properties across magnetism, energy, catalysis, and sensing.
Marisol Martín‐González
wiley +1 more source
Community Assembly and Functional Analysis of Rhizosphere Rare Bacteria in Daodi Angelica sinensis
【Objective】To analyze the diversity characteristics of rhizosphere bacteria of different ecotypes (wild, semi-wild and cultivated type) of Angelica sinensis in authentic producing areas, and to clarify the community assembly mechanisms and functional ...
Cheng YANG +6 more
doaj +1 more source

