Results 31 to 40 of about 198,332 (267)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
The Effectiveness of the UNAIDS Strategy«90-90-90»in Populations with Different Population Growth
Эпидемиология и вакцинопрофилактика, 2020 Introduction. Available data indicate that the effectiveness of the strategy of "90-90-90" varies considerably between countries. For example, Australia with figures 90-90-79 (2016) has not achieved the negative trend of the incidence and prevalence ...
D. A. Neshumaev +2 more
doaj +1 more source
The Past as a Stochastic Process
Journal of Computer Applications in Archaeology20 pages, 4 ...
David H. Wolpert +8 more
openaire +3 more sources
Combinatorial stochastic processes [PDF]
Stochastic Processes and their Applications, 1994 Well-known asymptotic results for sums of independent stochastic processes are extended to processes \(S = \sum^ n_{i = 1} \varphi_{i \pi (i)}\), where \(\varphi = (\varphi_{ij})_{1 \leq i,j \leq n}\) is a collection of independent stochastic processes \(\varphi_{ij}\) on some set \(\tau\), and \(\pi\) is a random permutation of \(\{1,2, \dots, n ...
openaire +2 more sources
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
On the Trackability of Stochastic Processes
CoRR, 2020 We consider the problem of tracking an unstable stochastic process $X_t$ by using causal knowledge of another stochastic process $Y_t$. We obtain necessary conditions and sufficient conditions for maintaining a finite tracking error. We provide necessary conditions as well as sufficient conditions for the success of this estimation, which is defined as
Baran Tan Bacinoglu +2 more
openaire +2 more sources