Results 51 to 60 of about 20,470,336 (306)
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Small RNA pathways in mammalian oocytes
FEBS Open Bio, EarlyView.Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley +1 more source
EntropyThree-phase induction motors are widely used in various industrial sectors and are responsible for a significant portion of the total electrical energy consumed.
Marlio Antonio Silva +7 more
doaj +1 more source
Frontiers in Integrative Neuroscience, 2018 The variability inherently present in biophysical data is partly contributed by disparate sampling resolutions across instrumentations. This poses a potential problem for statistical inference using pooled data in open access repositories.
Carla Caballero +5 more
doaj +1 more source
Densities for Stochastic Processes
The Annals of Mathematical Statistics, 1959 Let $\{x_\theta(t), \theta \varepsilon \Omega\}$ be a family of stochastic processes defined by their finite dimensional distributions; that is, $\{F_\theta\lbrack x(t_1), \cdots, x(t_n)\rbrack; \theta \varepsilon \Omega\}$ is given for all finite sets of time points $t_1, \cdots, t_n$.
openaire +3 more sources
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Economic Disposal Quantity of Leftovers kept in storage: a Monte Carlo simulation method
Open Engineering, 2019 This article describes how to reach an item’s threshold, or in other words, the limit time for it to be retrieved from stock and sold for a different use, as well as the remaining foreseen period for this situation to occur.
Assis R. +3 more
doaj +1 more source
Screening Routine Clinical Notes for Epilepsy Surgery Candidates Using Large Language Models
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Epilepsy surgery is severely underutilized despite proven efficacy, with substantial under‐referral of eligible patients in routine clinical practice. This study evaluated the potential role of large language models (LLMs) as decision‐support tools for screening unstructured clinical notes to identify epilepsy surgery candidates and ...
Uriel Fennig +9 more
wiley +1 more source
Pseudo-dynamic simulations applied to ball mill grinding circuit using population balance model and Monte Carlo Method [PDF]
REM: International Engineering JournalProcess simulations can be used to improve grinding circuit performance, which efficiently reduces operating costs. The population balance model (PBM) is widely accepted for grinding modeling because it can reproduce breakage events in tumbling mills, as
Jose Guilherme de Abreu Valadares +2 more
doaj +1 more source
A Generalized Age-Dependent Branching Process and Its Limit Distribution [PDF]
The Egyptian Statistical Journal, 1970 An age-dependent continuous parameter branching stochastic process Xₙ(t) is considered, where Xₙ (t) is the number of particles in the population at time t and N is the initial size of the population. If the probabilities of splits depend on N.
I. Shimi
doaj +1 more source