Results 61 to 70 of about 1,273,882 (314)
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Species DiversityTwo genera of the poorly known family Cetomimidae (flabby whalefishes), Cetomimus Goode and Bean, 1895 and Gyrinomimus Parr, 1934, are morphologically similar but differ in jaw tooth row (indistinct diagonal rows in Cetomimus vs.
Ryo Misawa +6 more
doaj +1 more source
Assessments of 14 Exploited Fish and Invertebrate Stocks in Chinese Waters Using the LBB Method
Frontiers in Marine Science, 2020 Due to limited data availability, only a small subset of the exploited fish and invertebrate populations have been assessed along Chinese coasts, which precludes comprehensive management of the fisheries.
Cui Liang +7 more
doaj +1 more source
An atlas of the growth, mortality and recruitment of Philippine fishes [PDF]
Growth, Mortality, Recruitment, Size distribution, Population dynamics, Fishery biology, Stock assessment, Length, Philippines ...
Ingles, J., Pauly, D.
core
Using experiments and expert judgment to model catchability of Pacific rockfishes in trawl surveys, with application to bocaccio (Sebastes paucispinis) off British Columbia [PDF]
, 2010 The time series of abundance indices for many groundfish populations, as determined from trawl surveys, are often imprecise and short, causing stock assessment estimates of abundance to be imprecise.
McAllister, Murdock K. +2 more
core
a4a assessment model simulation testing [PDF]
, 2013 The a4a initiative seeks to overcome these issues by developing a flexible, robust and easy to use stock assessment model, thus making stock assessment accessible to a wide range of scientists that do not have the high skilled quantitative background ...
FERRETTI MARCO +5 more
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source