Results 51 to 60 of about 601,557 (262)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Characterizing the complete mitogenome of Heterosentis holospinus Amin, Heckman & Ha, 2011 (Palaeacanthocephala: Echinorhynchida: Arhythmacanthidae) and its mitochondrial phylogeny

Mitochondrial DNA. Part B. Resources
Heterosentis holospinus Amin, Heckman & Ha, 2011 is a parasitic acanthocephalan, with Cynoglossus bilineatus Lacepède, 1802 identified as a new definitive host.
Feiming Chen, Hao Wu, Min Xie, Zhenzhen Xiong, Jia Cai, Yu Huang, Xiao Jin, Can Yang, Jinwei Gao, Rui Song   +9 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Study of manufacturing resource perception and process control of a radio-frequency-identification-enabled decentralized flexible manufacturing system

Advances in Mechanical Engineering, 2017
The fusion of mechatronics, communication, control, and information technologies has introduced new automation paradigms into the production environment.
Zengqiang Jiang, Mingcheng E, Yu Liu, Jianxin Liu, Yu Li   +4 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Etiology of Four Waves of the COVID-19 Pandemic in Ukraine according to the SARS-CoV-2 Virus Genome Sequencing Data: A Pilot Study

Microbiology Research
The COVID-19 pandemic in Ukraine, from March 2020 to June 2022, witnessed distinct waves, each characterized by an increase in cases and fatalities.
Alla Mironenko, Ihor Kravchuk, Larysa Radchenko, Nataliia Teteriuk, Olha Holubka, Liudmyla Bolotova, Mykola Pydiura, Andriy Goy   +7 more
doaj   +1 more source

THE RESULTS OF THE EFFICACY AND SAFETY OF THE NEW RUSSIAN DRUG 6НР IN THE ANTIRETROVIRAL THERAPY REGIMENS OF HIV-INFECTED PATIENTS

Журнал инфектологии, 2019
The aim of the study was to assess the efficacy and safety of ART regimens that included different doses of the drug 6НР with the reception of QD, in comparison with the scheme of ART, containing, PhAZT, to select the daily dose 6НР in conducting phase ...
A. V. Kravchenko, N. V. Sizova, S. V. Minaeva, O. A. Kozyrev, F. I. Nagimova, O. S. Efremova, D. A. Gusev, E. V. Ovsyannikova   +7 more
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Identification of non-volatile components and anti-fatigue effect of a compound Lujiu [PDF]

Zhongguo niangzao
The non-volatile compounds in a compound Lujiu (38%vol) was detected by high-performance liquid chromatography quadrupole time-of- flight tandem mass spectrometry (HPLC-Q-TOF-MS/MS).
CHEN Ying, ZHU Yuzhe, YU Meili, LIU Fangmei, LI Cunyu, ZHENG Yunfeng, PENG Guoping
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source