Results 71 to 80 of about 619,176 (260)

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

open access: yesFEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta   +7 more
wiley   +1 more source

Load Characteristics of B-type Metro Vehicle Bogie Frame

open access: yesChengshi guidao jiaotong yanjiu
Objective The international standards adopted in metro vehicle design and verification in China do not fully align with the actual vehicle operating conditions, resulting in the phenomenon of fatigue cracks in some metro vehicle bogie frames before ...
WANG Yuguang   +3 more
doaj   +1 more source

Pengendalian Persediaan Obat dengan Minimum-Maximum Stock Level di Instalasi Farmasi RSUP Dr. Sardjito Yogyakarta

open access: yesJurnal Manajemen dan Pelayanan Farmasi, 2019
Inappropriate inventory control of medicines in hospital can lead to shortage or over stock, which is a problem faced by Dr. Sardjito Hospital Yogyakarta. The aim of this study was to examine the effect of the Minimum-Maximum Stock Level (MMSL) method on
Titik Rahayu Indarti   +2 more
doaj   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

open access: yesFEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey   +4 more
wiley   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

open access: yesFEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen   +8 more
wiley   +1 more source

Statistical Control Charts: Performances of Short Term Stock Trading in Croatia

open access: yesBusiness Systems Research, 2015
Background: The stock exchange, as a regulated financial market, in modern economies reflects their economic development level. The stock market indicates the mood of investors in the development of a country and is an important ingredient for growth ...
Dumičić Ksenija, Žmuk Berislav
doaj   +1 more source

Audit Operasional: Solusi Atas Biaya DeadStock

open access: yesJurnal Akuntansi, 2018
In manufacturing company, effectiveness and efficiency of inventory control can affect the corporate earnings significantly. According to the observation, the author found a large number of dead stock at PT X.
Christian - Linardo   +2 more
doaj   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

open access: yesFEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata   +3 more
wiley   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

open access: yesFEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima   +8 more
wiley   +1 more source

Transcriptome analysis of Apostichopus japonicus early in the regeneration process after evisceration

open access: yesInvertebrate Survival Journal
In extreme salt stress and anaerobic conditions, Apostichopus japonicus survives by "evisceration." The species can eject its viscera and create a new organ if the habitat is suitable. The molecular response of A.
BC Wu   +7 more
doaj  

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