Results 101 to 110 of about 74,695 (306)
Knowledge and Management of Aquatic Ecosystems, 2014 Available knowledge on the ecological requirements of the twaite shad Alosa fallax larvae is limited, restricting the development of effective management and conservation measures for this anadromous clupeid in European rivers. In this study, the effects
Navarro T., Carrapato C., Ribeiro F.
doaj +1 more source
Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis
FEBS Open Bio, EarlyView.Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto +14 more
wiley +1 more source
OPTIMAL GRAZING PRESSURE UNDER OUTPUT PRICE AND PRODUCTION UNCERTAINTY WITH ALTERNATIVE FUNCTIONAL FORMS [PDF]
This study uses a Cox parametric bootstrap test to select between two specifications of the von Liebig hypothesis, a switching regression model and a non-linear mixed stochastic plateau function.
Kaitibie, Simeon +3 more
core
FEBS Open Bio, EarlyView.TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw +5 more
wiley +1 more source
Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito +8 more
wiley +1 more source
Genomic Baselines for Muskellunge in West Virginia: Implications for Stocking and Conservation
HydrobiologyMuskellunge (Esox masquinongy) are a recreationally and ecologically important apex predator found throughout North America. In West Virginia, the genetic structuring and diversity of native muskellunge is poorly understood. The supplementary stocking of
Andrew Johnson, Nate Taylor, Amy Welsh
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, 1985 Stocking intensity and stocking pressure have been defined and used as technical stocking variables describing animals on pasture. Relationships between these variables and stocking variables such as stocking density and stocking rate are discussed.
Scarnecchia, D. L.
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Introduction/Objective Acute intracranial stenting during endovascular thrombectomy (EVT) for ischemic stroke requires intraprocedural antiplatelet therapy (APT) to maintain patency. However, the hemorrhagic risk of combining APT with intravenous thrombolysis (IVT) remains uncertain.
Aaron Rodriguez‐Calienes +75 more
wiley +1 more source