Results 51 to 60 of about 14,228 (259)

Effect of Dietary Chlorogenic Acid on Growth Performance, Antioxidant Function, and Immune Response of Broiler Breeders under Immune Stress and Stocking Density Stress

Veterinary Sciences, 2022
The study was conducted to evaluate the effects of dietary chlorogenic acid supplementation on the growth performance, antioxidant function, and immune response of broiler breeders exposed to immune stress or high stocking density stress.
Dongying Bai, Kexin Liu, Xianglong He, Haiqiu Tan, Yanhao Liu, Yuqian Li, Yi Zhang, Wenrui Zhen, Cai Zhang, Yanbo Ma   +9 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Stocking Density and Homogeneity, Considerations on Pandemic Potential

Zoonotic Diseases, 2023
Zoonotic pathogens, an increasing threat to human health, typically originate in the wild but spill over to humans from domestic animals because of the high contact with them. Industrial farming involves an increased number of animals of a single species per given area. Such high stocking density facilitates pathogen transmission. This speeds evolution
Max J. Moreno-Madriñan, Eric Kontowicz
openaire   +2 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The Effect of different Stocking Density on Ammonia Content (NH3) and Nitrite (NO2) in Catfish (Clarias Sp.) with Biofloc Aquaculture System

Journal of Aquaculture Science, 2018
The accumulation of waste in aquaculture can cause inorganic toxins  named ammonia (NH3) and nitrite (NO2) in water. Biofloc technology is one of the new alternative to solve the problem of ammonia (NH3) and nitrite (NO2) in aquaculture techniques ...
Ahmad Nizar Fanani, Boedi Setya Rahardja, Prayogo .   +2 more
doaj   +1 more source

Stocking density mediated stress modulates growth attributes in cage reared Labeo rohita (Hamilton) using multifarious biomarker approach

Scientific Reports, 2022
The present study was conducted for 240 days to evaluate the effects of stocking density based on growth attributes, digestive enzymes, muscular composition, biochemical and physiological responses of Labeo rohita fingerlings in tropical inland open ...
Himanshu Sekhar Swain, Basanta Kumar Das, Aurobinda Upadhyay, Mitesh Hiradas Ramteke, Vikas Kumar, Dharmendra Kumar Meena, Uttam Kumar Sarkar, Narinder Kumar Chadha, Kiran Dube Rawat   +8 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

SEA RANCHING OF Holothuria atra: STOCKING DENSITY AND TIME

Biotropia: The Southeast Asian Journal of Tropical Biology, 2021
Strong market demand and uncontrolled exploitation and/or the inadequate management of fisheries have caused many stocks of sea cucumbers to be overexploited. One suggested effort to overcome this problem is sea ranching.
Retno Hartati, Ambariyanto Ambariyanto, Muhammad Zainuri, Widianingsih Widianingsih   +3 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source