Results 61 to 70 of about 22,482 (296)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Optimal Stocking Density for Dual-Purpose Winter Wheat Production [PDF]

, 2017
Dual-purpose winter wheat production is an important economic enterprise in the southern Great Plains of the United States. Because of the complex interactions involved in producing wheat grain and beef gain from a single crop, stocking density is an ...
Kaitibie, Simeon, Horn, Gerald W., Krenzer, Eugene G., Jr., Brorsen, B. Wade, Paisley, Steven I., Epplin, Francis M.   +5 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Determination of the best stocking density for rearing Huso huso [PDF]

, 2006
Effects of stocking density on growth, food conversion ratio, specific growth rate, percentage of body weight increase in Huso huso were studied in two phases. Juveniles below one year old with an average weight of 92.09±1.72 grams and stocking densities
Aghtoman, V., Mohseni, M., Sajadi, M.M., Pourali, H.R.   +3 more
core   +1 more source

Effect of stocking density on behavior, performance and some blood parameters of Muscovy ducks

SVU-International Journal of Veterinary Sciences, 2023
The aim of this experiment was to examine the effect of different stocking densities on behavior, performance, and some blood parameters of Muscovy ducks.
Eman Negm , Ahmed Mohammed
doaj   +1 more source

Effect of stocking density on pig production

, 2013
Numerous stressors such as environmental, nutritional, pathological or equipment related ones are operative in swine facilities. Among many factors, socking density increases social stress and influences pig performance.
Cho, JH, Kim, IH
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

The Effect of different Stocking Density on Ammonia Content (NH3) and Nitrite (NO2) in Catfish (Clarias Sp.) with Biofloc Aquaculture System

Journal of Aquaculture Science, 2018
The accumulation of waste in aquaculture can cause inorganic toxins  named ammonia (NH3) and nitrite (NO2) in water. Biofloc technology is one of the new alternative to solve the problem of ammonia (NH3) and nitrite (NO2) in aquaculture techniques ...
Ahmad Nizar Fanani, Boedi Setya Rahardja, Prayogo .   +2 more
doaj   +1 more source

Application of Biofloc Technology for the culture of Heteropneustes fossilis (Bloch) in Bangladesh: stocking density, floc volume, growth performance, and profitability

, 2022
Though Biofloc Technology is a new concept in Bangladesh, it provides advantages for improving aquaculture production in many countries, leading to achieve sustainable development goals.
Kawla, Mst Salamun, Rahman, Moshiur, Shamsuddin, Md, Rakib, Md Refat Jahan, Hossain, M Belal, Shufol, Md Badiul Alam, Rashid, Muhammad Mamunur, Asadujjaman, Md   +7 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source