Results 61 to 70 of about 2,510,408 (298)

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Stocking density influences common carp larval development. Can restocking processes activate compensatory growth consequent to previous high stocking density? [PDF]

, 2020
Aim of study: to analyse the effect of stocking density on common carp larvae production. Since stocking density is one of the most important variables in recirculating aquaculture system, it is fundamental to understand its implication on fish larval ...
Leonardo S. Glória, de Souza, André B., Fanttini Polese, Marcelo, Manuel V. Vidal Júnior, Motta, Jonas H. S., Manoel A. C. Neto, Motta, Jonas Henrique de Souza, Glória, Leonardo S., de Souza, André Batista, Vidal Júnior, Manuel V., Vazquez Vidal Júnior, Manuel, Jonas H. S. Motta, André B. de Souza, Marcelo F. Polese, Neto, Manoel A. C., Polese, Marcelo F.   +15 more
core   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Stocking density affects circadian rhythms of locomotor activity in african catfish, clarias gariepinus

, 2011
The effect of stocking density on the locomotor activity of African catfish C. gariepinus under different light regimes was investigated. C. gariepinus were stocked under different densities (1, 5, or 10 fish/tank), and their locomotor activity recorded ...
Migaud, Herve, Al‐Khamees, Sammi, Vera, LM   +2 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The Effect of different Stocking Density on Ammonia Content (NH3) and Nitrite (NO2) in Catfish (Clarias Sp.) with Biofloc Aquaculture System

Journal of Aquaculture Science, 2018
The accumulation of waste in aquaculture can cause inorganic toxins  named ammonia (NH3) and nitrite (NO2) in water. Biofloc technology is one of the new alternative to solve the problem of ammonia (NH3) and nitrite (NO2) in aquaculture techniques ...
Ahmad Nizar Fanani, Boedi Setya Rahardja, Prayogo .   +2 more
doaj   +1 more source

Historical Changes in Stocking Densities on Texas Rangelands [PDF]

Rangeland Ecology & Management, 2012
Stocking density, both current and past, is a major determinant of the nature and condition of rangelands. Despite this fact, there have been few detailed examinations of historical trends in stocking density. We used data from the U.S. Census of Agriculture to track the density of domestic livestock from the early 1900s to the present, for six ...
Bradford P. Wilcox, Michael G. Sorice, Jay Angerer, Cynthia L. Wright   +3 more
openaire   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source