Results 91 to 100 of about 1,649 (263)
CD4+ Tregs Drive Post‐Ischemic Sprouting Angiogenesis via Endothelial YY1/MAML1 Reactivation
Advanced Science, EarlyView.ABSTRACT Microvascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4+ regulatory T‐cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in immunodeficient mice impairs vascular regeneration.
Hang Qu +10 more
wiley +1 more source
Local Compactness and the Baire Category Theorem in Abstract Stone Duality
, 2003 Abstract Stone Duality is a re-axiomatisation of general topology intended to make it recursive. By turning the idea of the Scott topology on its head, notions that involve directed (infinitary) joins are reformulated using functions of higher type ...
Taylor, Paul
core +1 more source
Advanced Science, EarlyView.Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang +11 more
wiley +1 more source
Four extensions of the stone duality
, 2017 Este trabajo consiste principalmente en estudiar y presentar cuatro extensiones de la dualidad de Stone, para ello una idea esencial ser´a considerar las categor´ıas ABR y STR, luego se extender´an los funtores cl´asicos de Stone a estas categor´ıas y se
Ramirez Ardila, Edwar Alexis
core
Categorical Duality Theory: With Applications to Domains, Convexity, and the Distribution Monad [PDF]
, 2013 Utilising and expanding concepts from categorical topology and algebra, we contrive a moderately general theory of dualities between algebraic, point-free spaces and set-theoretical, point-set spaces, which encompasses infinitary Stone dualities, such as
Maruyama, Yoshihiro
core +1 more source
Enhancing Maturation of Human Neuromuscular Organoids via Electrical Stimulation
Advanced Science, EarlyView.A framework for on‐demand and non‐invasive exposure of human neuromuscular organoids (NMOs) to electrical stimuli is established to promote their maturation. The robustness and effectiveness of different stimulation regimes are evaluated via thorough characterization of organoid tissue structure and contraction capacity. Chronic electrical stimulation,
Chrysanthi‐Maria Moysidou +12 more
wiley +1 more source
Senolytic Therapy as a Preventive Strategy for Spine Degeneration and Pain
Advanced Science, EarlyView.Cellular senescence promotes inflammation, tissue degeneration, and chronic back pain. In sparc‐null mice, early oral administration of the senolytic agents o‐vanillin and RG‐7112 reduced senescent cell burden and pro‐inflammatory SASP signaling across intervertebral discs, endplates, vertebral bone, and spinal cord.
Saber Ghazizadeh +7 more
wiley +1 more source
Non-commutative Stone duality: inverse semigroups, topological groupoids and C*-algebras
, 2012 We study a non-commutative generalization of Stone duality that connects a class of inverse semigroups with a class of etale topological groupoids. We show how the Thompson-Higman groups arise via this construction as well as a range of important C ...
Lawson, Mark, M. V. Lawson
core +1 more source
Advanced Science, EarlyView.Cigarette smoke accelerates the aging of immune cells in the lung. By combining human single‐cell sequencing, cell culture, and mouse models, the authors show that the protein GEM drives mitochondrial damage and senescence in alveolar macrophages by suppressing SIRT3.
Jin Wang +8 more
wiley +1 more source