Results 121 to 130 of about 97,688 (273)

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Functional equivalence of imagined vs. real performance of an inhibitory task: an EEG/ERP study.

Frontiers in Human Neuroscience, 2016
Early neuroimaging and electrophysiological studies suggested motor imagery recruited a different network than motor execution. However, several studies have provided evidence for the involvement of the same circuits in motor imagery tasks, in the ...
Santiago Galdo-Alvarez, Fidel Mauricio Bonilla, Alberto Jacobo González-Villar, María Teresa Carrillo-de-la-Peña   +3 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

STOP-IT

, 2013
The stop-signal paradigm is a useful tool for the investigation of response inhibition (for a review, see Verbruggen & Logan, 2008). In 2008, Gordon Logan, Michael Stevens and Frederick Verbruggen developed a free program, called STOP-IT, for running the
Frederick Verbruggen (377419)
core  

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Dual neural mechanisms of sustained response inhibition: Right-lateralized core control and left-lateralized adaptive support

NeuroImage
Sustained inhibition is critical for adaptive behavioral control in complex environments, yet its neural underpinnings remain poorly understood. Using a sequence-selective stop-signal task, we hypothesized that increasing stop-signal delay (SSD) would ...
Liyue Lin, Jiahe Sun, Wei Xiong, Jiayi Zhao, Yishu Chen, Min Li, Xi Li, Ruyan Jiao, Zihao Zhou, Hongfei Ji, Jie Li, Jie Zhuang   +11 more
doaj   +1 more source

Striatal response to negative feedback in a stop signal task operates as a multi-value learning signal. [PDF]

Imaging Neurosci (Camb), 2023
Smith BJ, Lipsett M, Cosme D, Braun VA, O'Hagan AMB, Berkman ET.   +5 more
europepmc   +1 more source

Clinical Spectrum and Outcomes of SOX1 Antibody‐Associated Paraneoplastic Neurological Syndromes: A Chinese Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background SOX1 antibody‐positive paraneoplastic neurological syndromes (PNS) exhibit significant population‐specific clinical heterogeneity. While Western cohorts predominantly manifest Lambert‐Eaton myasthenic syndrome (65%–80%), comprehensive clinical characterization and treatment response data in Asian populations remain critically ...
Jin‐Long Ye, Zu‐Ying Kuang, Bo Li, Meng‐Qiu Pan, Li‐Hua Zhou, Yang‐Yang Dai, Si‐Fen Xie, Xian‐Guang Lin, Ye‐Peng Hu, Li‐Hong Jiang, Zhan‐Hang Wang, Wei‐Jing Zhang   +11 more
wiley   +1 more source

Proactive cues facilitate faster action reprogramming, but not stopping, in a response-selective stop signal task. [PDF]

Sci Rep, 2023
Salomoni SE, Gronau QF, Heathcote A, Matzke D, Hinder MR.   +4 more
europepmc   +1 more source