Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky +8 more
wiley +1 more source
Biomechanical Analysis of Unplanned Gait Termination According to a Stop-Signal Task Performance: A Preliminary Study. [PDF]
Brain Sci, 2023 Koo DK, Kwon JW.
europepmc +1 more source
Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani +8 more
wiley +1 more source
Sex moderates family history of alcohol use disorder and childhood maltreatment effects on an fMRI stop-signal task. [PDF]
Hum Brain Mapp, 2023 Elton A +5 more
europepmc +1 more source
The effects of alcohol on driver performance in a decision making situation [PDF]
, 1978 The results are reviewed of driving simulator and in-vehicle field test experiments of alcohol effects on driver risk taking. The objective was to investigate changes in risk taking under alcoholic intoxication and relate these changes to effects on ...
Allen, R. W. +3 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective People with epilepsy (PWE) may experience cognitive deficits but fail to undergo formal evaluation. This study compares cognitive status between PWE and healthy controls in the West African Republic of Guinea. Methods A cross‐sectional, case–control study was conducted in sequential recruitment phases (July 2024–July 2025) at Ignace ...
Maya L. Mastick +14 more
wiley +1 more source
Beyond Sparsity: Tree Regularization of Deep Models for Interpretability [PDF]
, 2017 The lack of interpretability remains a key barrier to the adoption of deep models in many applications. In this work, we explicitly regularize deep models so human users might step through the process behind their predictions in little time. Specifically,
Doshi-Velez, Finale +5 more
core +2 more sources
Neuropsychiatric Symptoms Mimicking Dementia in a Patient Treated With Imatinib
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Tyrosine kinase inhibitors are the cornerstone of chronic myeloid leukemia treatment. Newer agents have more potency and a broader spectrum of action, but also a higher potential for neuropsychiatric side effects. We present a case of a patient on imatinib who developed progressive cognitive, mood, and behavioral alterations.
Ashley Jones +3 more
wiley +1 more source
Failing to attend versus failing to stop: Single-trial decomposition of action-stopping in the stop signal task. [PDF]
Behav Res Methods, 2023 Hannah R, Muralidharan V, Aron AR.
europepmc +1 more source
, 2022 The stop signal task (SST) is a popular paradigm for assessing response inhibition, namely the ability to cancel or withhold irrelevant or inappropriate behaviours. On a subset of trials, a stop signal follows the go signal after the stop signal delay (SSD), urging the participants to cancel their already initiated response to the go signal.
openaire +1 more source