Results 201 to 210 of about 815,824 (234)

Auto‐Downregulation of the Florigen FT Production Prevents Precocious Flowering in Plants

Advanced Science, Volume 13, Issue 55, 5 October 2026.
This study shows that the leaf vein‐expressed FD complexes with the florigen FT to bind DNA motifs in FT promoter, which antagonizes CONSTANS‐mediated FT activation to feedback down‐regulate FT expression. This prevents an excessive induction of FT expression by inductive photoperiods, thereby precluding precocious transition to flowering in ...
Shu Tian, Xiao Luo, Bowen Cui, Yuehui He
wiley   +1 more source

A conserved in-frame stop codon acts as a multipotent defense mechanism in alphaviruses. [PDF]

Sci Adv
Bhattacharya T, Freeman TS, Alleman EM, Wang F, Chechik L, Emerman M, Myles KM, Malik HS.   +7 more
europepmc   +1 more source

Microprotein MP104 Promotes Malignant Progression of Colorectal Cancer Through Regulating Protein Translation

Advanced Science, Volume 13, Issue 56, 9 October 2026.
A previously unrecognized microprotein, MP104, encoded by ZEB1‐AS1, emerges as a critical driver of colorectal cancer progression. MP104 links ubiquitin‐mediated protein degradation with translational reprogramming via the UBE2O–AMPKα2–mTOR–EIF4B axis, revealing an unrecognized layer of oncogenic regulation.
Fang Chen, Miao Wang, Hongmei Yong, Jin Ding, Shiping Xu, Qirui Ge, Yan Wang, Lei Zhang, Qianqian Xiao, Benli Li, Li Lin, Sufang Chu, Qianqing Wang, Jin Bai, Pingfu Hou   +14 more
wiley   +1 more source

Rpd3L regulates transcription-replication conflict via H3K4 methylation-dependent and -independent chromatin mechanisms. [PDF]

Sci Adv
Chong SY, Chen YL, Hsu YT, Hsu CL, Lu TM, Lo YC, Kao CF.   +6 more
europepmc   +1 more source

SIZ1‐Mediated SUMOylation of LBD29 Recruits ARF7 to Fine‐Tune Auxin Signaling in Lateral Root Development

Advanced Science, Volume 13, Issue 56, 9 October 2026.
Our findings establish SUMOylation as a key post‐translational control layer in auxin signaling. We show that SIZ1‐mediated SUMOylation of LBD29 promotes its association with ARF7, stabilizing a transcriptional hub that governs lateral root development.
Jiaxuan Sui, Qianlan Yin, Yiying Chen, Liping Zhang, Xiuyuan Yu, Qianqian Yu, Zhaojun Ding, Xiangpei Kong   +7 more
wiley   +1 more source

Molecular Basis and Clinical Significance of the High-risk Phenotype of Hepatitis B Virus Genotype C. [PDF]

J Clin Transl Hepatol
Huang C, Liu Z, Zhang J, Shen T, Sang L.
europepmc   +1 more source

Mapping Mutations and Signaling Network Interactions to Guide Precision Therapy in Gallbladder Cancer

Cancer Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background Gallbladder cancer (GBC) is a biologically complex malignancy arising from the epithelial lining of the gallbladder, with adenocarcinoma constituting the major histological subtype. Early detection is challenging because of vague clinical manifestations and the organ's deep‐seated anatomical location, resulting in diagnosis at ...
Nisha Manav, Akanksha Kashyap, Lakshay Malhotra, Chethan Rajegowda, Chandra Prakash Prasad   +4 more
wiley   +1 more source

Impact of the Diversity in the 5' UTR on Translation Regulation. [PDF]

Wiley Interdiscip Rev RNA
Cardamone G, Flohr M, Bode I, Schmid T.
europepmc   +1 more source

Genomic and Phenotypic Characterization of Two Novel Enterobacter Phages With EDTA‐Enhanced Antibiofilm Activity

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Two novel lytic Enterobacter phages, HHH and RZH, displayed targeted antibiofilm activity against MDR Enterobacter cloacae complex biofilms when combined with EDTA. Activity was strongest within a narrow low‐millimolar EDTA window, reducing biofilm biomass and viable burden, while higher EDTA concentrations shifted the interaction towards antagonism ...
Kashif Haq, Zac Newland‐Smith, Martin Figgit, David Lee, Kwabena Duedu   +4 more
wiley   +1 more source

Dysregulated m⁶A via compensatory arginine methylation primes premalignancy in metabolic dysfunction-associated steatotic liver disease. [PDF]

Sci Adv
Kim GD, Choi D, Kim SY, Jeong H, Kang G, Eom SJ, Eom S, Park J, Lee HS, Yang I, Sung JK, Nam KT, Park YN, Chi SW, Koo SH.   +14 more
europepmc   +1 more source