Results 71 to 80 of about 49,360 (273)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Alpha- and beta-band oscillations subserve different processes in reactive control of limb movements

Frontiers in Behavioral Neuroscience, 2014
The capacity to rapidly suppress a behavioral act in response to sudden instruction to stop is a key cognitive function. This function, called reactive control, is tested in experimental settings using the stop signal task, which requires subjects to ...
Pierpaolo ePani, Fabio eDi Bello, Emiliano eBrunamonti, Valeria eD'Andrea, Odysseas ePapazachariadis, Stefano eFerraina   +5 more
doaj   +1 more source

Exploring stop signal reaction time over two sessions of the anticipatory response inhibition task [PDF]

, 2022
Various behavioural tasks measure response inhibition encompassing the ability to cancel unwanted actions, evaluated via stop signal reaction time (SSRT).
McDonald, Hayley J., Hall, Alison, MacDonald, Hayley J; id_orcid, Jenkinson, Ned, MacDonald, Hayley J., Jenkinson, Ned; id_orcid   +5 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Release the BEESTS: Bayesian Estimation of Ex-Gaussian STop-Signal Reaction Time Distributions

Frontiers in Psychology, 2013
The stop-signal paradigm is frequently used to study response inhibition. Inthis paradigm, participants perform a two-choice response time task wherethe primary task is occasionally interrupted by a stop-signal that promptsparticipants to withhold their ...
Dora eMatzke, Jonathon eLove, Thomas V Wiecki, Scott D Brown, Gordon D Logan, Eric-Jan eWagenmakers   +5 more
doaj   +1 more source

Behavioral results ToM and stop-signal task for both groups.

, 2013
Behavioral results ToM and stop-signal task for both groups.
Lisette van der Meer (144354), André Aleman (91646), Nynke A. Groenewold (288918), Marieke Pijnenborg (434685)   +3 more
core   +1 more source

Gender Differences in Cognitive Control: an Extended Investigation of the Stop Signal Task [PDF]

Brain Imaging and Behavior, 2009
Men and women show important differences in clinical conditions in which deficits in cognitive control are implicated. We used functional magnetic resonance imaging to examine gender differences in the neural processes of cognitive control during a stop-signal task.
Li, Chiang-shan Ray, Zhang, Sheng, Duann, Jeng-Ren, Yan, Peisi, Sinha, Rajita, Mazure, Carolyn M.   +5 more
openaire   +4 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

The Stop-Signal Paradigm

, 2018
Response inhibition—the ability to stop responses that are no longer appropriate—is frequently studied with the stop‐signal paradigm. In the stop‐signal paradigm, participants perform a choice response time task that is occasionally interrupted by a stop
Frederick Verbruggen, Dora Matzke, Gordon D. Logan, Logan, G.D., Verbruggen, F., Matzke, D.   +5 more
core   +2 more sources

Event-related potentials for post-error and post-conflict slowing. [PDF]

PLoS ONE, 2014
In a reaction time task, people typically slow down following an error or conflict, each called post-error slowing (PES) and post-conflict slowing (PCS). Despite many studies of the cognitive mechanisms, the neural responses of PES and PCS continue to be
Andrew Chang, Chien-Chung Chen, Hsin-Hung Li, Chiang-Shan R Li   +3 more
doaj   +1 more source