Results 41 to 50 of about 127,164 (309)
A systematic survey of randomised trials that stopped early for reasons of futility
BMC Medical Research Methodology, 2020 Background Randomised trial protocols may incorporate interim analyses, with the potential to stop the study for futility if early data show insufficient promise of a treatment benefit. Previously, we have shown that this approach will theoretically lead
S. D. Walter +7 more
doaj +1 more source
Machine learning methods for fission product identification from Bragg curves
AIP Advances, 2023 A fission time projection chamber (fission-TPC) was developed to provide precise neutron-induced fission measurements for several major actinides. As fission fragments lose energy in one of the gas volumes of the fission-TPC, energy loss information is ...
S. M. Lyons +6 more
doaj +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
When Goal-Setting Forges Ahead but Stops Short [PDF]
SSRN Electronic Journal, 2020 In this study, we use at scale randomized control trial among 18,000 secondary students in 181 schools in Tanzania (Zanzibar) to examine the effects of personal best goal-settings on students’ academic performance. We also offer non-financial rewards to students to meet the goals they set.
Islam, Asad +5 more
openaire +4 more sources
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Phase- and GVF-Based Level Set Segmentation of Ultrasonic Breast Tumors
Journal of Applied Mathematics, 2012 Automatically extracting breast tumor boundaries in ultrasound images is a difficult task due to the speckle noise, the low image contrast, the variance in shapes, and the local changes of image intensity.
Liang Gao, Xiaoyun Liu, Wufan Chen
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Belief Propagation Decoder With Multiple Bit-Flipping Sets and Stopping Criteria for Polar Codes
IEEE Access, 2020 Compared with successive cancellation list (SCL) decoders, belief propagation (BP)-based decoders suffer performance loss in middle-and high-signal-to-noise ratio (SNR) regions.
Jianyong Zhang, Muguang Wang
doaj +1 more source
Legal regulation of the international road transport of passengers [PDF]
Zbornik Radova: Pravni Fakultet u Novom Sadu, 2017 Since March 2013 bus and coach passengers have a minimum set of rights when travelling in the European Union. Regulation 181/2011 concerning the rights of passengers in bus and coach transport applies to passengers traveling with regular services that ...
Đurđev Dušanka J.
doaj +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source