Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
The content of active constituents of stored sliced and powdered preparations of turmeric rhizomes and zedoary (bulb and finger) rhizomes [PDF]
The stability of active constituents (curcuminoids and volatile oil) in turmeric (Curcuma longa Linn.) rhizomes and zedoary [Curcuma zedoaria (Berg.) Roscoe] bulb and finger rhizomes during storage have been investigated. They were prepared as sliced and
Sanan Subhadhirasakul +2 more
doaj
Antimicrobial storage conditions: authors’ response [PDF]
E. S. Mitema, G. M. Kikuvi
openaire +1 more source
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Postharvest conservation of the tuberous roots of
This paper aimed to evaluate the effects of storage periods on the conservation of Pachyrhizus ahipa roots at different temperatures and packaging materials.
ROSILDA M. MUSSURY +5 more
doaj
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
EFFECT OF STORAGE LONGEVITY UNDER DIFFERENT STORAGE CONDITIONS ON SEED VIGOR AND OIL CONTENT IN MAIZE, SOYBEAN AND SUNFLOWER [PDF]
The study aimed to examine the changes in seed vigor and oil content in different genotypes of maize, soybean and sunflower over three years (2002-2005) in two type storage conditions differed in terms of air temperature and humidity: 25°C/75% and 12°C ...
B. Šimić +4 more
doaj
The effects of storage conditions on viability of Clostridium difficile vegetative cells and spores and toxin activity in human faeces [PDF]
AIMS: Clostridium difficile is a common nosocomial pathogen and as such diagnostic and research methods may necessitate storage of faecal specimens for long periods, followed by subsequent re-examination.
Freeman, J., Wilcox, M.H.
core +1 more source
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Oxidative Stress Associated with Chilling Injury in Immature Fruit: Postharvest Technological and Biotechnological Solutions [PDF]
Immature, vegetable-like fruits are produced by crops of great economic importance, including cucumbers, zucchini, eggplants and bell peppers, among others. Because of their high respiration rates, associated with high rates of dehydration and metabolism,
Carvajal Moreno, Fátima +5 more
core +1 more source

