Results 111 to 120 of about 9,595,472 (294)
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
The content of active constituents of stored sliced and powdered preparations of turmeric rhizomes and zedoary (bulb and finger) rhizomes [PDF]
Songklanakarin Journal of Science and Technology (SJST), 2007 The stability of active constituents (curcuminoids and volatile oil) in turmeric (Curcuma longa Linn.) rhizomes and zedoary [Curcuma zedoaria (Berg.) Roscoe] bulb and finger rhizomes during storage have been investigated. They were prepared as sliced and
Sanan Subhadhirasakul +2 more
doaj
Is Storage at a Loss Merely an Illusion of Spatial Aggregation? [PDF]
The storage-at-a-loss paradox—stocks despite inadequate price growth to cover storage costs—is an unresolved issue of long-standing interest to economists.
Franken, Jason R.V. +2 more
core
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Postharvest conservation of the tuberous roots of
Anais da Academia Brasileira de Ciências, 2013 This paper aimed to evaluate the effects of storage periods on the conservation of Pachyrhizus ahipa roots at different temperatures and packaging materials.
ROSILDA M. MUSSURY +5 more
doaj
EFFECT OF STORAGE LONGEVITY UNDER DIFFERENT STORAGE CONDITIONS ON SEED VIGOR AND OIL CONTENT IN MAIZE, SOYBEAN AND SUNFLOWER [PDF]
Poljoprivreda, 2005 The study aimed to examine the changes in seed vigor and oil content in different genotypes of maize, soybean and sunflower over three years (2002-2005) in two type storage conditions differed in terms of air temperature and humidity: 25°C/75% and 12°C ...
B. Šimić +4 more
doaj
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source