Results 71 to 80 of about 5,420,398 (301)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Finite element modeling of a beam-column connection in industrial storage racking structures

open access: yes, 2013
Industrial storage racking structures are typically constructed using cold-formed steel sections and contain moment resisting frames in which the columns have slots punched in at regular intervals to enable the beams to be clipped into position at any ...
Firouzianhaji, A   +5 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Stability analysis of steel storage rack structures

open access: yes, 2014
Industrial racks are normally framed structures fabricated from cold-formed sections and relative to their self weight (Dead Load) carry very high Pallet Loads (live load) compared with conventional civil engineering structures. Lack of sufficient design
Firouzianhaji, A   +5 more
core  

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

open access: yesMolecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad   +2 more
wiley   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani   +9 more
wiley   +1 more source

Introduction to industrial carbon capture and storage

open access: yes, 2016
Carbon capture and storage, or CCS, is a process used to capture carbon dioxide gas (CO2) that is produced by power stations or other types of industrial facilities.
Global Carbon Capture and Storage Institute
core  

Density Functional Theory-Based Approaches to Improving Hydrogen Storage in Graphene-Based Materials

open access: yesMolecules
Various technologies have been developed for the safe and efficient storage of hydrogen. Hydrogen storage in its solid form is an attractive option to overcome challenges such as storage and cost. Specifically, hydrogen storage in carbon-based structures
Heriberto Cruz-Martínez   +5 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso   +5 more
wiley   +1 more source

Seed storage prolamins

open access: yes
The development of a molecular classification of seed storage prolamins in the post-genomic era provides insights into the relationships between these proteins from different cereal species that were not possible when relying on the traditional ...
Xu, Q.   +4 more
core   +1 more source

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