Results 31 to 40 of about 2,072,425 (306)
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Assessing Users’ Satisfaction with Cassava Processing Centre Via Nigerian Stored Products Research Institute (NSPRI) Adopted Villages Scheme in Isale Awe, Kwara State, Nigeria [PDF]
The study assessed users’ satisfaction with cassava processing centre via Nigerian Stored Products Research Institute (NSPRI) Adopted Villages Scheme in Isale Awe, Kwara State, Nigeria.
Patrick Kayode Orimafo +3 more
doaj +1 more source
A Virtual Observatory Vision based on Publishing and Virtual Data [PDF]
We would like to propose a vision of the Virtual Observatory where the "killer-app" is seen to be generalizing and extending the idea of "publication" from the narrow meaning of peer-reviewed journals.
Hanisch, Robert +2 more
core
Function‐driven design of a surrogate interleukin‐2 receptor ligand
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
The study focused on the profit efficiency of garri processors at the post-harvest value chain in Rivers State, Nigeria. A purposive sampling procedure and snowballing techniques were used to select 120 respondents for this study.
Ogechi Nwahia +5 more
doaj +1 more source
In the present study, the microbiological safety and the proximate analyses of five urban markets within Ilorin-West Local Government Area, Kwara State, Nigeria were carried out using standard protocols.
C.O. Adetunji +4 more
doaj +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Studies on In-vitro Anti-inflammatory and Antioxidant Potentials of Annona muricata Leaf Extracts
Inflammation has stimulated significant worldwide scientific interest because of its implication in many human diseases. Most inflammations are caused by reactive oxygen species or free radicals.
IDORENYIN NWAEHUJOR +3 more
doaj +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source

