Results 41 to 50 of about 1,560,905 (327)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Sphincterochilidae from Tunisia, with a note on the subgenus Rima Pallary, 1910 (Gastropoda, Pulmonata) [PDF]

, 2011
In order to establish an updated checklist of terrestrial gastropod from Tunisia, a revision of the species of Sphincterochilidae is presented, using bibliographic and museum records and the results of our own field work.
Abbes, Intidhar, Nouira, Said, Neubert, Eike   +2 more
core   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Multiplex STR amplification sensitivity in a silicon microchip [PDF]

, 2018
The demand for solutions to perform forensic DNA profiling outside of centralized laboratories is increasing. We here demonstrate highly sensitive STR amplification using a silicon micro-PCR (mu PCR) chip.
Colle, Frederik, Cornelis, Senne, Deforce, Dieter, Fauvart, Maarten, Gansemans, Yannick, Stakenborg, Tim, Van Nieuwerburgh, Filip, Vander Plaetsen, Ann-Sophie, Wiederkehr, Rodrigo S   +8 more
core   +2 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Sexually dimorphic tibia shape is linked to natural osteoarthritis in STR/Ort mice [PDF]

, 2018
Human osteoarthritis (OA) is detected only at late stages. Male STR/Ort mice develop knee OA spontaneously with known longitudinal trajectory, offering scope to identify OA predisposing factors.
A.A. Pitsillides, Altman, Arden, B. Javaheri, Bailey, Baliunas, Burger, Callewaert, Chambers, Chambers, Comhaire, Cooper, Das-Gupta, De Souza, Doube, Felson, Felson, Glasson, Goldring, Gregson, Guettler, H. Razi, Hardcastle, Hardcastle, Hardcastle, I. Maric-Mur, Javaheri, Javaheri, Javaheri, Kilkenny, Kyostio-Moore, Lajeunesse, Longo, M. Hopkinson, M. Piles, Mason, Naruse, Nevitt, P.D. Lee, Pasold, Poulet, Poulet, R. de Souza, Razi, Schneider, Sharma, Silverstein, Sowers, Spector, Stok, Strong, Tetsworth, Uchida, Vincelette, Walton, Walton, Y.-M. Chang, Zhang   +57 more
core   +4 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Post-concussive syndrome in a female basketball player: a case study

Open Access Journal of Sports Medicine, 2013
Sarah L StrandDepartment of Health and Human Sciences, Loyola Marymount University, Los Angeles, CA, USAAbstract: The objective of this case study was to identify the signs and symptoms of concussion and post-concussive syndrome in a collegiate, female ...
Str, SL
doaj  

Authentication of newly established human esophageal squamous cell carcinoma cell line (YM-1) using short tandem repeat (STR) profiling method [PDF]

, 2016
Cross-contamination during or early after establishment of a new cell line could result in the worldwide spread of a misidentified cell line. Therefore, newly established cell lines need to be authenticated by a reference standard method.
Ayyoob, K., Jahanbakhsh, A., Masoud, K., Vahideh, K.   +3 more
core  

Comparative studies of Population Synthesis Models in the frame work of modified Str\"{o}mgren filters

, 2014
Evolutionary models form a vital part of stellar population research to understand their evolution, but despite their long history of development, they often misrepresent and misinterpret the properties of stellar population observed through broadband ...
Hensler, Gerhard, Rakos, Karl, Sreedhar, Yuvraj Harsha   +2 more
core   +1 more source