Results 51 to 60 of about 636,342 (244)

DFT CALCULATED FOR VIBRATION FREQUENCIES AND IR ABSORPTION INTENSITIES OF [6] CYCLACENE (ARMCHAIR) MOLECULE [PDF]

مجلة جامعة الانبار للعلوم الصرفة, 2012
تم حساب ترددات الاهتزاز وشدد امتصاص طیف الاشعة تحت الحمراء, لجمیع الاحداثیات الداخلیة لجزیئة [6] سایکلاسین نوع (Armchair) و بعددها 3N–6)) و مناقشتها تماثلیا و تأصریا وفق نظریة دوال الکثافة (DFT) وباسلوب (B3LYP) وعناصر قاعدة (6-311G).
REHAB M. KUBBA
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Improving Conductivity Image Quality Using Block Matrix-based Multiple Regularization (BMMR) Technique in EIT: A Simulation Study

Journal of Electrical Bioimpedance, 2011
A Block Matrix based Multiple Regularization (BMMR) technique is proposed for improving conductivity image quality in Electrical Impedance Tomography (EIT).
Bera Tushar Kanti, Biswas Samir Kumar, Rajan K., Nagaraju J.   +3 more
doaj   +1 more source

Presenting a Stock Market Model based on Risk Appetite, Investor Sentiment, and Monetary Policy Shock Using Smooth Transition Regression (STR) [PDF]

راهبرد مدیریت مالی
This article seeks to provide a model to investigate the reaction of the stock market index, risk-taking and investors' sentiments to the monetary policy shock in the form of non-linear models.
Mohsen Hamidian, Ali Baghani, Nastaran Ahmadi   +2 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

CSYseq Y-STR mutation analysis.

, 2021
A. Individual Y-STR mutation rates with their 95% CIs. The RM Y-STR treshold (10−2 mpg, dashed line) and average mutation rate (4.57×10−3 mpg, black line) are indicated. B.
Simon Vanpaemel (11401754), Maarten Larmuseau (3264285), Paulien Verstraete (11401748), Ronny Decorte (655794), Sofie Claerhout (155858), Liesbeth Warnez (11401751)   +5 more
core   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Screening for streptomycin resistance-conferring mutations in Mycobacterium tuberculosis clinical isolates from Poland. [PDF]

PLoS ONE, 2014
Currently, mutations in three genes, namely rrs, rpsL, and gidB, encoding 16S rRNA, ribosomal protein S12, and 16S rRNA-specific methyltransferase, respectively, are considered to be involved in conferring resistance to streptomycin (STR) in ...
Tomasz Jagielski, Helena Ignatowska, Zofia Bakuła, Łukasz Dziewit, Agnieszka Napiórkowska, Ewa Augustynowicz-Kopeć, Zofia Zwolska, Jacek Bielecki   +7 more
doaj   +1 more source

Proportions of different types of small variants in the STR and not in STR regions.

, 2023
(a) The proportions of deletions, insertions, and SNVs in STR regions and (b) not in STR regions. The analysis was performed on high-confidence small variant sets from two individuals from the Platinum Genome and six individuals from GIAB. The numbers on
Ning Wang (108353), Sofia Khan (79890), Laura L. Elo (61005)   +2 more
core   +1 more source