Results 41 to 50 of about 1,550,459 (297)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Post-concussive syndrome in a female basketball player: a case study

Open Access Journal of Sports Medicine, 2013
Sarah L StrandDepartment of Health and Human Sciences, Loyola Marymount University, Los Angeles, CA, USAAbstract: The objective of this case study was to identify the signs and symptoms of concussion and post-concussive syndrome in a collegiate, female ...
Str, SL
doaj  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Evaluation of genetic parameters of 23 autosomal STR loci in a Southern Chinese Han population

Annals of Human Biology, 2018
Aim: To evaluate the 23 autosomal short tandem repeat (STR) loci included in GoldenEye™ 25 A kit using forensic human identification and paternity testing.
Hai-xia Li, Dan Peng, Ying Wang, Ri-ga Wu, Yin-ming Zhang, Ran Li, Hong-yu Sun   +6 more
doaj   +1 more source

Imaging electric fields in the vicinity of cryogenic surfaces using Rydberg atoms

, 2015
The ability to characterize static and time-dependent electric fields in situ is an important prerequisite for quantum-optics experiments with atoms close to surfaces.
Agner, J. -A., Deiglmayr, J., Merkt, F., Schmutz, H., Stammeier, M., Thiele, T., Wallraff, A.   +6 more
core   +1 more source

Yield gains in extra-early maize cultivars of three breeding eras under multiple environments [PDF]

, 2017
Open Access JournalAvailability of extra-early maize cultivars has facilitated the expansion of maize production into savannas of West and Central Africa (WCA).
A. O. Talabi, Akaogu, B. Annor, B. Badu-Apraku, Badu-Apraku, Badu-Apraku, Badu-Apraku, Badu-Apraku, Badu-Apraku, Badu-Apraku, Badu-Apraku, Badu-Apraku, Badu-Apraku, Badu-Apraku, Badu-Apraku, Badu-Apraku, Badu-Apraku, Badu-Apraku, Bremner, Bänziger, C. G. Yallou, Campos, Castleberry, Cechin, Crossa, Duvick, Fajemisin, Falconer, Gauch, Gauch, H. Alidu, I. C. Akaogu, IITA, K. Obeng-Antwi, Kamara, Kim, Kim, M. Aderounmu, M. Oyekunle, Moghaddam, NeSmith, O’Neill, Sabaghnia, Sadeghi, Sangoi, SAS Institute, Soil Survey Staff, Tollenaar, Wang, Wolfe, Yan, Yan, Zobel   +52 more
core   +2 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source