Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Post-concussive syndrome in a female basketball player: a case study
Open Access Journal of Sports Medicine, 2013 Sarah L StrandDepartment of Health and Human Sciences, Loyola Marymount University, Los Angeles, CA, USAAbstract: The objective of this case study was to identify the signs and symptoms of concussion and post-concussive syndrome in a collegiate, female ...
Str, SL
doaj
In Situ Profiling of Nanoscale Strains Uncovers Mechano-Architectural Predictors of Aging and Osteoarthritis Emergence. [PDF]
Adv Sci (Weinh)In situ mechanical loading of osteoarthritis‐prone murine knee joints reveals that spatial alterations in subchondral plate microarchitecture precede cartilage loss and promote a shift from coordinated epiphyseal strain dissipation in healthy joints to focal subchondral strain concentration in osteoarthritis‐prone joints.
Sharma A +10 more
europepmc +2 more sources
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Evaluation of genetic parameters of 23 autosomal STR loci in a Southern Chinese Han population
Annals of Human Biology, 2018 Aim: To evaluate the 23 autosomal short tandem repeat (STR) loci included in GoldenEye™ 25 A kit using forensic human identification and paternity testing.
Hai-xia Li +6 more
doaj +1 more source
STR: US leads in hotel openings during pandemic
, 2020 STR is reporting that the U.S. opened more hotels than any other country throughout the course of the pandemic.
STR
core
Identificação humana: uma proposta metodológica para obtenção de DNA de ossos e implementação de banco de dados de frequências alélicas de STRs autossômicos na população de Santa Catarina [PDF]
, 2009 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-graduação em BiotecnologiaNos casos forenses, cadáveres ou suas partes são encontrados em diferentes estágios de decomposição, sendo nestes ...
Moreti, Tiago
core
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Expanded and mega-plex STR panels as a tool for presumptive population assignment [PDF]
Historically, forensic STR panels have been unsuccessful for population assignment due to the limited ancestry information that can be derived from the non-coding STR loci and the low number of loci included in the panel.
Dawnay, L, Dawnay, N, Flamson, R
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source