Results 61 to 70 of about 1,550,459 (297)

Screening for streptomycin resistance-conferring mutations in Mycobacterium tuberculosis clinical isolates from Poland. [PDF]

open access: yesPLoS ONE, 2014
Currently, mutations in three genes, namely rrs, rpsL, and gidB, encoding 16S rRNA, ribosomal protein S12, and 16S rRNA-specific methyltransferase, respectively, are considered to be involved in conferring resistance to streptomycin (STR) in ...
Tomasz Jagielski   +7 more
doaj   +1 more source

Separation of Blood Mixtures Using Fluorescently Labeled Antibodies [PDF]

open access: yes, 2017
Identifying and analyzing biological mixture samples at a crime scene are of paramount concern for forensic scientists, especially if that type of evidence contains only one cell type. The presence of multiple contributors in a biological evidence sample
Jabado, Dani
core   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Application of Multiple Kits in Special Parentage Testing Cases [PDF]

open access: yesFayixue Zazhi, 2018
Objective To analyse the genetic polymorphism of 21 autosome STR loci in Han population of Shandong Province and the cases with loci mutation or allelic loss typed by Goldeneye?誖DNA identification system 25A. Methods Totally 40 autosome STR loci types of
GAO Hong-mei, WANG Chang, ZHANG Shan-shan,et al.
doaj   +1 more source

The apparent shape of the "Str\"omgren sphere'' around the highest-redshift QSOs with Gunn-Peterson troughs

open access: yes, 2004
Although the highest redshift QSOs (z>6.1) are embedded in a significantly neutral background universe (mass-averaged neutral hydrogen fraction >1%) as suggested by the Gunn-Peterson absorption troughs in their spectra, the intergalactic medium in their ...
Couderc P., Qingjuan Yu, Rees M. J.
core   +1 more source

Quasar Str\"omgren Spheres Before Cosmological Reionization [PDF]

open access: yes, 2000
Ionizing sources embedded in the neutral intergalactic medium (IGM) before cosmological reionization generate discrete HII regions. We show that a sufficiently bright quasar (for example, one tenth as luminous as that recently discovered by Fan et al ...
Cen, Renyue, Haiman, Zoltan
core   +2 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

The Use of Short Tandem Repeat Analysis for Cell Line Authentication

open access: yesБиопрепараты: Профилактика, диагностика, лечение, 2019
Short tandem repeat analysis (STR) is a well-established international method of authentication and genetic stability testing of cell lines (CLs). Therefore, the development and introduction of this method into routine practice of cell banks and cell ...
M. D. Khorolsky   +3 more
doaj   +1 more source

A review of dance-flies of the Empis (s. str.) pennipes group of species (Diptera: Empididae) from the Caucasus, with descriptions of five new species [PDF]

open access: yesКавказский энтомологический бюллетень, 2014
The paper includes a review of dance-flies (Empididae) of the Empis (s. str.) pennipes group from the territory of the Caucasus that is based on materials housed in the Zoological Institute of Russian Academy of Sciences, St. Petersburg, and in Kuban
S.Yu. Kustov, I.V. Shamshev
doaj   +1 more source

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