RIPK4 function interferes with melanoma cell adhesion and metastasis
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
The Use of Short Tandem Repeat Analysis for Cell Line Authentication
Short tandem repeat analysis (STR) is a well-established international method of authentication and genetic stability testing of cell lines (CLs). Therefore, the development and introduction of this method into routine practice of cell banks and cell ...
M. D. Khorolsky +3 more
doaj +1 more source
Electrical conductivity of the hippocampal CA1 layers and application to current-source-density analysis [PDF]
The microstructure of the layers in the hippocampal CA1 area suggests that differences may exist between the electrical conductivities of these layers.
Holsheimer, J.
core +2 more sources
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
A review of dance-flies of the Empis (s. str.) pennipes group of species (Diptera: Empididae) from the Caucasus, with descriptions of five new species [PDF]
The paper includes a review of dance-flies (Empididae) of the Empis (s. str.) pennipes group from the territory of the Caucasus that is based on materials housed in the Zoological Institute of Russian Academy of Sciences, St. Petersburg, and in Kuban
S.Yu. Kustov, I.V. Shamshev
doaj +1 more source
A targeted gene panel that covers coding, non-coding and short tandem repeat regions improves the diagnosis of patients with neurodegenerative diseases [PDF]
Genetic testing for neurodegenerative diseases (NDs) is highly challenging because of genetic heterogeneity and overlapping manifestations. Targeted-gene panels (TGPs), coupled with next-generation sequencing (NGS), can facilitate the profiling of a ...
Au, Wing Chi +11 more
core +1 more source
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Model-Based Real-Time Head Tracking
This paper treats real-time tracking of a human head using an analysis by synthesis approach. The work is based on the Structure from Motion (SfM) algorithm from Azarbayejani and Pentland (1995).
Ström Jacob
doaj +1 more source
Performance of oscillatory flow reactor and stir tank reactor in solvent fermentation from palm oil mill effluent [PDF]
Advance in mixing technology has developed a new way of mixing fluids by introducing an oscillatory motion to replace the conventional mechanical agitation or an air bubble displacement.
Hassan Kadhum, Abdul Amir +4 more
core
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source

