Results 41 to 50 of about 4,519,520 (279)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Progress on Partial Edge Drawings

Journal of Graph Algorithms and Applications, 2017
Recently, a new way of avoiding crossings in straight-line drawings of non-planar graphs has been introduced. The idea of partial edge drawings (PED) is to drop the middle part of edges and rely on the remaining edge parts called stubs.
Till Bruckdorfer, Sabine Cornelsen, Carsten Gutwenger, Michael Kaufmann, Fabrizio Montecchiani, Martin Nöllenburg, Alexander Wolff   +6 more
doaj   +1 more source

Drawing Clustered Planar Graphs on Disk Arrangements

Journal of Graph Algorithms and Applications, 2020
Let $G=(V, E)$ be a planar graph and let $\mathcal V$ be a partition of $V$. We refer to the graphs induced by the vertex sets in $\mathcal V$ as clusters.
Tamara Mchedlidze, Marcel Radermacher, Ignaz Rutter, Nina Zimbel   +3 more
doaj   +1 more source

On Planar Straight-Line Dominance Drawings

CoRR
We study the following question, which has been considered since the 90's: Does every $st$-planar graph admit a planar straight-line dominance drawing? We show concrete evidence for the difficulty of this question, by proving that, unlike upward planar straight-line drawings, planar straight-line dominance drawings with prescribed $y$-coordinates do ...
Patrizio Angelini, Michael A. Bekos, Giuseppe Di Battista, Fabrizio Frati, Luca Grilli, Giacomo Ortali   +5 more
openaire   +6 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Straight-Line Drawings on Restricted Integer Grids in Two and Three Dimensions

Journal of Graph Algorithms and Applications, 2003
This paper investigates the following question: Given a grid ϕ, where ϕ is a proper subset of the integer 2D or 3D grid, which graphs admit straight-line crossing-free drawings with vertices located at (integral) grid points of ϕ?
Stefan Felsner, Giuseppe Liotta, Stephen Wismath   +2 more
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Drawing Subcubic 1-Planar Graphs with Few Bends, Few Slopes, and Large Angles

Journal of Graph Algorithms and Applications, 2021
We show that the $1$-planar slope number of $3$-connected cubic $1$-planar graphs is at most four when edges are drawn as polygonal curves with at most one bend each, that is, any such graph admits a drawing with at most one bend per edge and such that ...
Philipp Kindermann, Fabrizio Montecchiani, Lena Schlipf, André Schulz   +3 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Algorithms and Characterizations for 2-Layer Fan-planarity: From Caterpillar to Stegosaurus

Journal of Graph Algorithms and Applications, 2017
In a fan-planar drawing of a graph there is no edge that crosses two other independent edges. We study 2-layer fan-planar drawings, i.e., fan-planar drawings such that the vertices are restricted to two distinct horizontal layers and edges are straight ...
Carla Binucci, Markus Chimani, Walter Didimo, Martin Gronemann, Karsten Klein, Jan Kratochvíl, Fabrizio Montecchiani, Ioannis Tollis   +7 more
doaj   +1 more source