Results 51 to 60 of about 7,574 (255)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Journal of Graph Algorithms and Applications, 2017 We introduce a new type of graph drawing called "rook-drawing". A rook-drawing of a graph $G$ is obtained by placing the $n$ nodes of $G$ on the intersections of a regular grid, such that each row and column of the grid supports exactly one node.
David Auber +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
On a Class of Planar Graphs with Straight-Line Grid Drawings on Linear Area
Journal of Graph Algorithms and Applications, 2009 A straight-line grid drawing of a planar graph G is a drawing of G on an integer grid such that each vertex is drawn as a grid point and each edge is drawn as a straight-line segment without edge crossings.
Md. Rezaul Karim, Md. Saidur Rahman
doaj +1 more source
Morphing tree drawings in a small 3D grid
Journal of Graph Algorithms and Applications, 2023 We study crossing-free grid morphs for planar drawings of trees using the third dimension. A morph consists of morphing steps, where vertices of the tree move simultaneously along straight-line trajectories at constant speeds.
Elena Arseneva +2 more
doaj +1 more source
Straight-Line Orthogonal Drawings of Binary and Ternary Trees [PDF]
, 2008 In this paper we provide upper and lower bounds on the area requirement of straight-line orthogonal drawings of n-node binary and ternary trees. Namely, we show algorithms for constructing orderpreserving straight-line orthogonal drawings of binary trees in O(n1.5) area, straight-line orthogonal drawings of ternary trees in O(n1.631) area, and straight-
openaire +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
On the Complexity of the Planar Slope Number Problem
Journal of Graph Algorithms and Applications, 2017 The planar slope number of a planar graph $G$ is defined as the minimum number of slopes that is required for a crossing-free straight-line drawing of $G$.
Udo Hoffmann
doaj +1 more source
Orthogonal and Straight-Line Drawings of Graphs with Succinct Representations [PDF]
, 1999 The concept of a hierarchical design has played an important role in various areas of computer science and engineering, including software engineering, CAD, among others. Graphs with hierarchical structures, which are capable of describing large-scale regular structures in a succinct manner, have naturally become an interesting and important modeling ...
Ho-Lin Chen, Hsu-Chun Yen
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source