Results 51 to 60 of about 4,519,520 (279)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
1-Bend Orthogonal Partial Edge Drawing
Journal of Graph Algorithms and Applications, 2014 Recently, a new layout style to avoid edge crossings in straight-line drawings of non-planar graphs received attention. In a Partial Edge Drawing (PED), the middle part of each segment representing an edge is dropped and the two remaining parts ...
Till Bruckdorfer +2 more
doaj +1 more source
An Ongoing Project to Improve the Rectilinear and the Pseudolinear Crossing Constants
Journal of Graph Algorithms and Applications, 2020 A drawing of a graph in the plane is pseudolinear if the edges of the drawing can be extended to doubly-infinite curves that form an arrangement of pseudolines, that is, any pair of these curves crosses precisely once.
Oswin Aichholzer +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Computing Radial Drawings on the Minimum Number of Circles
Journal of Graph Algorithms and Applications, 2005 A radial drawing is a representation of a graph in which the vertices lie on concentric circles of finite radius. In this paper we study the problem of computing radial drawings of planar graphs by using the minimum number of concentric circles.
Emilio Di Giacomo +3 more
doaj +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Journal of Graph Algorithms and Applications, 2017 We introduce a new type of graph drawing called "rook-drawing". A rook-drawing of a graph $G$ is obtained by placing the $n$ nodes of $G$ on the intersections of a regular grid, such that each row and column of the grid supports exactly one node.
David Auber +3 more
doaj +1 more source
EXPLORATION OF BATIK JAMBI ON LEARNING TRANSFORMATION GEOMETRY
Prima: Jurnal Pendidikan Matematika, 2023 Geometry Ability is one of the mathematical abilities that must be mastered by students, this is because geometry ability is one part of learning mathematics.
retno andriyani +4 more
doaj +1 more source
, 2005 Concert listings in The Georgia Straight featuring a short blurb on the Al Neil Project's performance at The Roundhouse Centre.
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Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source