Results 61 to 70 of about 3,534,625 (310)

A Micro-Processor-Based Feedback Stabilization Scheme for High-Q, Non-Linear Silicon Resonators

Applied Sciences, 2016
Stabilization of silicon micro-resonators is a key requirement for their inclusion in larger photonic integrated circuits. In particular, thermal refractive index shift in non-linear applications can detune devices from their optimal working point.
Giuseppe Cantarella, Michael J. Strain
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

A polarisation maintaining fibre Bragg grating interrogation system for multi- axis strain sensing [PDF]

, 2002
Fibre Bragg gratings (FBGs) written into polarisation maintaining (PM) fibres have been employed for multi-axis strain and temperature sensing. In this paper we report the development of a FBG interrogation system that is capable of detecting ...
Steven E. Staines, Staines, Stephen E., Ye, Chen-Chun, Ralph P. Tatam, Tatam, Ralph P., Chen-Chun Ye, James, Stephen W., Stephen W. James   +7 more
core   +1 more source

Strain y strain rate para dummies Strain and strain rate for dummies

Revista Colombiana de Cardiología, 2011
Desarrollos recientes en el campo de la ecocardiografía han permitido a los cardiólogos cuantificar de manera objetiva la función miocárdica regional y global con base en los conceptos de deformación (strain) y velocidad de deformación (strain rate) que pueden calcularse de manera no invasiva tanto en el ventrículo izquierdo como en el derecho, y ...
Pastor Olaya, Jairo Sánchez, Luis Fernando Osio   +2 more
openaire   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Development genetic and stability classification of seasonal glacial lakes in a tectonically active area—A case study in Niangmuco, east margin of the Eastern Himalayan Syntaxis

Frontiers in Earth Science
The Niangmuco region on the east margin of the Eastern Himalayan Syntaxis features a large number of glacial lakes. The development process and stability classification of glacial lakes is of great significance to the study of seasonal glaciers in the ...
Yongyi Wei, Yongyi Wei, Liyun Jia, Liyun Jia, Xiumin Ma, Xiumin Ma, Zhe Lei, Zhe Lei   +7 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

A continuous/discontinuous Galerkin formulation for a strain gradient-dependent damage model

, 2004
The numerical solution of strain gradient-dependent continuum problems has been hindered by continuity demands on the basis functions. The presence of terms in constitutive models that involve gradients of the strain field means that the $C^0$ continuity
G. N. Wells, MOLARI, LUISA, K. Garikipati   +2 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source